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Facile preparation of iridium-based AIE polymer dots for sensitive electrochemiluminescence immunoassay of CD44 protein.

Anal Chim Acta

March 2025

Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, PR China; Department of Chemistry, Sungkyunkwan University, Suwon, 16419, Republic of Korea. Electronic address:

The development of aggregation-induced emission (AIE) luminophores is a fascinating and promising topic in electrochemiluminescence (ECL) bioanalysis. Herein, the AIE-active but water-insoluble [Ir(bt)₂(acac)] (bt = 2-phenylbenzothiazole, acac = acetylacetonate) was encapsulated within poly(styrene-maleic anhydride) (PSMA) using a simple nanoprecipitation method. This encapsulation strategy could effectively limit the free motion of Ir(bt)₂(acac) and trigger the aggregation-induced electrochemiluminescence (AIECL) effect.

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Mitochondrial dysfunction is involved in numerous diseases and the aging process. The integrated stress response (ISR) serves as a critical adaptation mechanism to a variety of stresses, including those originating from mitochondria. By utilizing mass spectrometry-based cellular thermal shift assay (MS-CETSA), we uncovered that phosphatidylethanolamine-binding protein 1 (PEBP1), also known as Raf kinase inhibitory protein (RKIP), is thermally stabilized by stresses which induce mitochondrial ISR.

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Dy/Tb co-doped glasses have drawn profound attention for their potential in solid state lighting due to their unique luminescence properties. This research highlights the effect of compositional variation on structural and optical characteristics of Dy/Tb co-doped phospho-tellurite glasses through a comprehensive analysis involving X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR) and photoluminescence (PL) studies. XRD and FTIR spectroscopy are conducted to characterize the glass matrix and confirm its structural integrity.

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Two-dimensional (2D) materials are highly valued for their unique properties and potential applications, as they can display exotic behaviors differing from those of their bulk forms. Research on elementary and binary solids has been making great progress recently, while synthesizing multi-component 2D materials experimentally remains a challenge, despite the possibility of greatly extending the number of members of the 2D realm. In this study, we synthesized ternary BiTeX (X = Cl, Br, I) nanosheets with high crystallinity through an electrochemical exfoliation method.

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Background: Due to their acidic nature, certain medications can have deleterious effects on tooth enamel. Fluoride is a popular method for reversing these effects. Therefore, this study aimed to assess the impact of acidic medications, specifically anti-asthmatic drugs and vitamin C tablets, on enamel surfaces and to investigate the effects of fluoride following drug exposure.

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