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In vitro and in vivo immune-enhancing effects of polysaccharides with different molecular weights and structural characteristics from Gastrodia elata Blume.
Int J Biol Macromol
January 2025
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macao. Electronic address:
Research on high-molecular-weight polysaccharides tends to be more difficult and lag in terms of their fine structures and bioavailability. We focused on Gastrodia elata Blume polysaccharides (GEPs) with different molecular weights and structural characteristics to reveal their bioactivities, especially those abundant high-molecular-weight GEPs. A novel high-yield polysaccharide (GEP1-2) with the high molecular weight of 3.
View Article and Find Full Text PDFTyrosinase-Catalyzed Peptide Stapling Using para-Amino Phenylalanine and Tyrosine Anchoring Residues.
Angew Chem Int Ed Engl
January 2025
Second Military Medical University, School of Pharmacy, 325 Guohe Road, 200433, Shanghai, CHINA.
Peptide stapling techniques have historically relied on metal-catalyzed chemical reactions, with no examples using enzymes. Here, inspired by tyrosinase-mediated oxidation, we describe the efficient side-chain to side-chain coupling of p-amino phenylalanine (Z) and tyrosine (Y) amino acids using a commercially available tyrosinase. Stapling reactions between the i, i+3 to i, i+7 positions were all performed, proceeding in good conversion and under mild conditions compatible with various side chains, functional motifs and ring sizes, with the Z-Y product found to be more stable and obtained in a higher yield than the Y-Z product.
View Article and Find Full Text PDFRealizing real-time optical molecular imaging in peripheral nerve tissue via Rhodamine B.
Front Med (Lausanne)
November 2024
Department of Orthopaedics, First Hospital of Shanxi Medical University, Taiyuan, China.
Background: Iatrogenic nerve injury is a consequential complication during surgery. Thus, real-time imaging of peripheral nerve (PN) possesses significant clinical implications. In recent years, the rapid advancements in optical molecular imaging (OMI) technology have provided essential technical foundations for the implementation of PN fluorescence imaging.
View Article and Find Full Text PDFPreparation and characterization of oleo-gum-resin-loaded electrospun nanofibers and evaluating its wound healing activity in two rat models of skin scar and burn wound.
Front Pharmacol
November 2024
Departamento de Ciencias del Ambiente, Facultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile.
Background: A growing body of research is dedicated to developing new therapeutic agents for wound healing with fewer adverse effects. One of the proceedings being taken today in wound healing research is to identify promising biological materials that not only heal wounds but also vanish scarring. The effectiveness of nanofibers like polyvinyl alcohol (PVA), in improving wound healing can be related to their unique properties.
View Article and Find Full Text PDFPersistent and severe hypotension during radical transabdominal ovarian cancer surgery: A case report.
Medicine (Baltimore)
December 2024
Department of Anesthesiology, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, Sichuan, China.
Rationale: In radical surgery for ovarian cancer (OC), hypotension that is difficult to correct is usually rare unless there is significant blood loss. We recently encountered a patient who developed persistent and severe hypotension during radical transabdominal OC surgery.
Patient Concerns: A patient was 52 years old with a history of hypertension and well-controlled preoperative blood pressure (BP).
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