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Loss of PV interneurons in the BLA may contribute to altered network and behavioral states in chronically epileptic mice.
eNeuro
January 2025
Tufts University School of Medicine, Department of Neuroscience, Boston, MA, USA.
Psychiatric disorders, including anxiety and depression, are highly comorbid in people with epilepsy. However, the mechanisms mediating the shared pathophysiology are currently unknown. There is considerable evidence implicating the basolateral amygdala (BLA) in the network communication of anxiety and fear, a process demonstrated to involve parvalbumin-positive (PV) interneurons.
View Article and Find Full Text PDFThe safety, accuracy, and feasibility of robotic assistance in neuro-oncological surgery.
Neurosurg Focus
December 2024
1Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida; and.
Article Synopsis
- Robotic technology in neurosurgery has progressed significantly over the last 30 years, enhancing the precision and safety of neuro-oncological surgeries through systems like the Robotic Surgical Assistant (ROSA).
- A study reviewed records of 348 patients who underwent procedures using ROSA, focusing on biopsy and laser interstitial thermal therapy, with results showing a high diagnostic yield of 98.6% and minimal complications.
- The research highlighted that complications were rare, with only 2 patients experiencing issues that resolved, and no permanent deficits were observed during an average follow-up period of 4.4 months.
How I do it: MRI-guided stereotactic navigation for Laser Interstitial Thermal Therapy.
Acta Neurochir (Wien)
November 2024
Department of Neurosurgery, Copenhagen University Hospital, Copenhagen, Denmark.
Background: MR-guided stereotaxy has emerged as a viable alternative to CT-guided frame-based or frameless approaches. By offering direct MR-guided navigation, this technique addresses most limitations inherent to CT navigation, enabling submillimeter precision.
Method: We detail the workflow of using the ClearPoint® MR navigation system for laser catheter placement in the treatment of a hypothalamic hamartoma.
Development of a murine laser interstitial thermotherapy system.
Neurosurg Focus
November 2024
1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, Florida; and.
Objective: The objective of this study was to develop a murine system for the delivery of laser interstitial thermotherapy (LITT) with probe-based thermometry as a model for human glioblastoma treatment to investigate thermal diffusion in heterogeneous brain tissue.
Methods: First, the tissue heating properties were characterized using a diode-pumped solid-state near-infrared laser in a homogeneous tissue model. The laser was adapted for use with a repurposed stereotactic surgery frame utilizing a micro laser probe and Hamilton syringe.
Stealth Autoguide as Robotic Holder for Cranial Endoscopic Surgery: Technical Note and Proof of Concept.
World Neurosurg
December 2024
Neurosurgery Department, ARNAS Civico Di Cristina Benfratelli Hospital, Palermo, Italy.
Background: The Stealth Autoguide (Medtronic, Minneapolis, MN) is a robotic auto-targeting device for stereotactic brain biopsy, placement of stereoelectroencephalography electrodes, and laser ablation therapy. This paper evaluates its off-label application as robotic endoscope holder in transnasal and intraventricular neurosurgery. The potential to enhance stability, reduce manual adjustments, and improve surgical precision is discussed, alongside cost-effectiveness and feasibility.
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