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Self-Guided Smartphone App (Vimbo) for the Reduction of Symptoms of Depression and Anxiety in South African Adults: Pilot Quantitative Single-Arm Study.
JMIR Form Res
January 2025
Private Practice, Ballito, South Africa.
Background: Barriers to mental health assessment and intervention have been well documented within South Africa, in both urban and rural settings. Internationally, evidence has emerged for the effectiveness of technology and, specifically, app-based mental health tools and interventions to help overcome some of these barriers. However, research on digital interventions specific to the South African context and mental health is limited.
View Article and Find Full Text PDFSurrogate End Points for Overall Survival in Neoadjuvant Randomized Clinical Trials for Early Breast Cancer.
J Clin Oncol
January 2025
German Breast Group, Neu-Isenburg, Germany.
Purpose: To assess trial-level surrogacy value for overall survival (OS) of the pathologic complete response (pCR) and invasive disease-free survival (iDFS) in randomized clinical trials (RCTs) for early breast cancer (BC).
Methods: Individual patient data of neoadjuvant RCTs with available data on pCR, iDFS, and OS were included in the analysis. We used the coefficient of determination from weighted linear regression models to quantify the association between treatment effects on OS and on the surrogate end points.
Transforming RN-Baccalaureate Education Using Insights From a National Faculty Needs Assessment.
Nurse Educ
January 2025
Author Affiliations: Arizona State University Edson College of Nursing and Health Innovation, Phoenix, Arizona (Dr Heywood); Wichita State University School of Nursing, Wichita, Kansas (Dr Williams); Southern New Hampshire University Nursing and Health Professions Department, Manchester, New Hampshire (Dr Blackwell); Bemidji State University Department of Nursing, Bemidji, Minnesota (Dr Hommes); University of Mississippi Medical Center School of Nursing, Jackson, Mississippi (Professor Franklin); and Boise State University School of Nursing, Boise, Idaho (Dr Nichols).
Background: The recent American Association of Colleges of Nursing (AACN) Essentials revision emphasizes direct clinical experiences across 4 spheres of care in RN-Baccalaureate (RN-B) education, creating challenges for online, asynchronous programs. Differentiating between prelicensure and postlicensure education complicates the integration of these requirements. Understanding RN-B faculty needs is critical for curricular transformation.
View Article and Find Full Text PDFMicroRNA-221 protects myocardial contractility in myocardial ischemia/reperfusion injury through phospholamban.
PLoS One
January 2025
Department of Pathology, 906 Hospital of Joint Logistic Support Force of PLA, Ningbo, Zhejiang, China.
Objective: To investigate the effects and mechanisms of miRNA 221 on myocardial ischemia/reperfusion injury (MIRI) in mice through the regulation of phospholamban (PLB) expression.
Methods: The MIRI mouse model was created and mice were divided into sham, MIRI, MIRI+ 221, and MIRI+ scr groups, with miRNA 221 overexpression induced in the myocardium of MIRI mice by targeted myocardial injection. Quantitative RT-PCR analysis was performed to observe the variation in miRNA 221, PLB, SERCA2, RYR2, NCX1, Cyt C and caspase 3 mRNA levels in myocardium, while Western blot assessed the levels of PLB, p-PLB (Ser16), p-PLB (Thr17), SERCA2, RYR2, NCX1, Cyt C and caspase 3 proteins.
Identification of cuproptosis and ferroptosis-related subtypes and development of a prognostic signature in colon cancer.
PLoS One
January 2025
Department of Gastroenterology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Colon cancer, as a highly prevalent malignant tumor globally, poses a significant threat to human health. In recent years, ferroptosis and cuproptosis, as two novel forms of cell death, have attracted widespread attention for their potential roles in the development and treatment of colon cancer. However, the investigation into the subtypes and their impact on the survival of colon cancer patients remains understudied.
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