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Developing an Indocyanine Green Angiography Protocol for Predicting Flap Necrosis During Breast Reconstruction.
Surg Innov
January 2025
Department of Breast Surgery, Chris O'Brien Lifehouse, Camperdown, NSW, Australia.
Background: Although there is evidence that indocyanine green angiography (ICGA) can predict mastectomy skin flap necrosis during breast reconstruction, consensus on optimal protocol is lacking. This study aimed to evaluate various technical factors which can influence ICG fluorescence intensity and thus interpretation of angiograms.
Method: Single institution retrospective study (2015-2021) of immediate implant-based breast reconstructions postmastectomy using a standardized technique of ICGA, controlling for modifiable factors of ambient lighting, camera distance and ICG dose.
Association of Novel Clinical and Behavioural Markers with HbA1c Improvement: A Latent Class Analysis of 912 Patients with Type 2 Diabetes Mellitus.
Diabetes Res Clin Pract
December 2024
Family Medicine Academic Clinical Program, Duke-NUS Medical School, Singapore; Program in Health Services and Systems Research, Duke-NUS Medical School, Singapore; Centre of Population Health Research and Implementation, SingHealth Regional Health System, Singapore; Division of Population Health and Integrated Care, Singapore General Hospital, Singapore; Research and Translational Innovation, SingHealth Community Hospitals, Singapore. Electronic address:
Objective: The escalating prevalence of Type 2 Diabetes Mellitus (T2DM) overwhelms healthcare systems. Lifestyle interventions enhancing patient monitoring and adherence vary in efficacy, emphasizing the need to understand differential response across patient subgroups. This study aimed to segment patients with T2DM into distinct latent classes and identify characteristics associated with optimal 12-month glycated haemoglobin (HbA1c) reduction.
View Article and Find Full Text PDFApplications and potential of machine learning augmented chest X-ray interpretation in cardiology.
Minerva Cardiol Angiol
November 2024
Annalise.ai, Sydney, Australia.
The chest X-ray (CXR) has a wide range of clinical indications in the field of cardiology, from the assessment of acute pathology to disease surveillance and screening. Despite many technological advancements, CXR interpretation error rates have remained constant for decades. The application of machine learning has the potential to substantially improve clinical workflow efficiency, pathology detection accuracy, error rates and clinical decision making in cardiology.
View Article and Find Full Text PDFOptimization of fluorinated phenyl azides as universal photocrosslinkers for semiconducting polymers.
Nat Commun
July 2024
Department of Chemistry, National University of Singapore, Lower Kent Ridge Road, S117552, Singapore, Singapore.
Fluorinated phenyl azides (FPA) enable photo-structuring of π-conjugated polymer films for electronic device applications. Despite their potential, FPAs have faced limitations regarding their crosslinking efficiency, and more importantly, their impact on critical semiconductor properties, such as charge-carrier mobility. Here, we report that azide photolysis and photocrosslinking can achieve unity quantum efficiencies for specific FPAs.
View Article and Find Full Text PDFEnzyme-Activatable Near-Infrared Hemicyanines as Modular Scaffolds for in vivo Photodynamic Therapy.
Angew Chem Int Ed Engl
July 2024
Centre for Inflammation Research, The University of Edinburgh, EH16 4UU, Edinburgh, UK.
Photodynamic therapy is an anti-cancer treatment that requires illumination of photosensitizers to induce local cell death. Current near-infrared organic photosensitizers are built from large and non-modular structures that cannot be tuned to improve safety and minimize off-target toxicity. This work describes a novel chemical platform to generate enzyme-activatable near-infrared photosensitizers.
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