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The emerging role of 12/15-lipoxygenase in ischemic stroke.
Brain Res Bull
January 2025
Department of Pharmacology, School of Basic Medicine, Zhengzhou University, Zhengzhou, China; Institute of Clinical Pharmacology, School of Basic Medicine, Zhengzhou University, Zhengzhou, China. Electronic address:
The arachidonic acid metabolic pathway is a classic inflammatory pathway. 12/15-lipoxygenase (LOX), a member of the lipoxygenase family that metabolizes arachidonic acid, has been implicated in the pathogenesis of numerous central nervous system (CNS) diseases. Ischemic stroke is a devastating disease in which the occlusion of cerebral arteries leads to a series of pathophysiological changes in brain tissue, triggering an inflammatory cascade within the brain that results in neuroinflammation.
View Article and Find Full Text PDFOverfeeding and overweight rapidly reprogram inflammatory signaling.
Clin Immunol
January 2025
Division of Immunology, Boston Children's Hospital, Boston, MA, United States of America. Electronic address:
Epidemiologic studies have shown a continuous increase in mortality risk associated with overweight, thus highlighting the health risks beginning before the onset of obesity. However, early changes in inflammatory signaling induced by an obesogenic diet remain largely unknown since studies of obesity typically utilize models induced by months of continuous exposure to a high-fat diet. Here, we investigated how short-term overfeeding remodels inflammatory signaling.
View Article and Find Full Text PDFHousing Temperature Influences Metabolic Phenotype of Heart Failure with Preserved Ejection Fraction in J vs N Strain C57BL/6 Mice.
Mol Cell Endocrinol
January 2025
Division of Cardiology, Department of Internal Medicine, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI 48105, USA; Ann Arbor VA Healthcare System, 2215 Fuller Rd, Ann Arbor, MI 48105, USA. Electronic address:
Preclinical heart failure studies rely heavily on mouse models despite their higher metabolic and heart rates compared to humans. This study examines how mouse strain (C57BL/6J vs. C57BL/6N) and housing temperature (23°C vs.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Bonn-Aachen International Center for IT (b-it), Bonn, Germany.
Background: Alzheimer's Disease (AD) is associated with sleep disturbances. Moreover, individuals with sleep disturbances have been reported to have a higher risk for developing AD. The measurement of sleep behavior therefore opens the opportunity for a potential digital biomarker of AD.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.
Background: Speech abnormalities are increasingly recognized as a manifestation of cognitive deficits in Alzheimer's disease (AD) and its preclinical and prodromal stages. Here, we investigated whether MRI measures of brain atrophy, specifically in the basal forebrain and cortical language areas, can predict cognitive decline and speech difficulties in older adults within the AD spectrum.
Method: The ongoing Prospect-AD study aims to develop an algorithm to automatically identify speech biomarkers in individuals with early signs of AD.
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