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Health Econ Rev
January 2025
Finnish Institute for Health and Welfare, PO Box 30, 00271, Helsinki, Finland.
Background: Healthcare expenditures have risen in middle- and high-income countries. One of the potential contributors is the overuse of diagnostics. I explore whether medical imaging is overused when privately owned clinics in Finland treat patients with voluntary private health insurance (VPHI).
View Article and Find Full Text PDFBiometrics
January 2025
Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London WC1E 7HT, United Kingdom.
The ICH E9 addendum on estimands in clinical trials provides a framework for precisely defining the treatment effect that is to be estimated, but says little about estimation methods. Here, we report analyses of a clinical trial in type 2 diabetes, targeting the effects of randomized treatment, handling rescue treatment and discontinuation of randomized treatment using the so-called hypothetical strategy. We show how this can be estimated using mixed models for repeated measures, multiple imputation, inverse probability of treatment weighting, G-formula, and G-estimation.
View Article and Find Full Text PDFThis paper sheds light on how spaces become contested sites for identity construction and negotiation to take place. Applying the Social Representations Approach, a qualitative study of 10 focus group discussions (n = 39), was conducted in Singapore, Malaysia and the UK to explore how, and why racialised identity construction changed in each socio-political context. The study challenged two underlying assumptions in social psychology: (1) that the meaning of the racialised category holds constant across time and space, and (2) there exists a pan-racial identification among Asian identities, for example, which at times allows for racialised categories to be manipulated as variables.
View Article and Find Full Text PDFLanguage is a sophisticated cognitive skill that relies on the coordinated activity of cerebral cortex. Acquiring a second language creates intricate modifications in brain connectivity. Although considerable studies have evaluated the impact of second language acquisition on brain networks in adulthood, the results regarding the ultimate form of adaptive plasticity remain inconsistent within the adult population.
View Article and Find Full Text PDFJ Am Med Inform Assoc
January 2025
Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA 19104, United States.
Objective: To develop a distributed algorithm to fit multi-center Cox regression models with time-varying coefficients to facilitate privacy-preserving data integration across multiple health systems.
Materials And Methods: The Cox model with time-varying coefficients relaxes the proportional hazards assumption of the usual Cox model and is particularly useful to model time-to-event outcomes. We proposed a One-shot Distributed Algorithm to fit multi-center Cox regression models with Time varying coefficients (ODACT).
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