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Cerebral Microbleeds and Amyloid Pathology Estimates From the Amyloid Biomarker Study.
JAMA Netw Open
January 2025
Alzheimer Center Limburg, Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, the Netherlands.
Importance: Baseline cerebral microbleeds (CMBs) and APOE ε4 allele copy number are important risk factors for amyloid-related imaging abnormalities in patients with Alzheimer disease (AD) receiving therapies to lower amyloid-β plaque levels.
Objective: To provide prevalence estimates of any, no more than 4, or fewer than 2 CMBs in association with amyloid status, APOE ε4 copy number, and age.
Design, Setting, And Participants: This cross-sectional study used data included in the Amyloid Biomarker Study data pooling initiative (January 1, 2012, to the present [data collection is ongoing]).
Diagnosis and practical management of digoxin toxicity: a narrative review and consensus.
Eur J Emerg Med
December 2023
Translational and Clinical Research Institute, Newcastle University & NPIS (Newcastle), Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
There are currently no universally accepted guidelines for the management of digoxin toxicity. In the absence of clinical practice guidelines, a set of consensus recommendations for management of digoxin toxicity in the clinical setting were developed through a modified Delphi approach. The recommendations highlight the importance of early recognition of signs of potentially life-threatening toxicity that requires immediate treatment with digoxin-specific antibodies.
View Article and Find Full Text PDFPredictors for selective flexure mobilization during robotic anterior resection for rectal cancer: a prospective cohort analysis.
Surg Endosc
July 2023
Amphia Ziekenhuis, Molengracht 21, 4818CK, Breda, Netherlands.
Introduction: Splenic flexure mobilization (SFM) may be indicated during anterior resection to provide a tension-free anastomosis. However, to date, no score allows identifying patients who may benefit from SFM.
Methods: Patients who underwent robotic anterior resection for rectal cancer were identified from a prospective register.
Early Effects of Nivolumab and Ipilimumab Combined Immunotherapy in the Treatment of Metastatic Melanoma in Poland: A Multicenter Experience.
Biomedicines
October 2022
The Maria Skłodowska-Curie National Research Institute of Oncology, Kraków Branch, 31-115 Krakó, Poland.
Nivolumab and ipilimumab combination became the first-line standard in advanced melanoma. We assessed its efficacy in a real-life study in Poland. In a one-year follow-up, we evaluated the medical records of 50 melanoma patients treated with that modality in five oncology centers.
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