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Importance of OsRac1 in Signalling of Pigm-1 Mediated Resistance to Rice Blast Disease.
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College of Agriculture and Plant Immunity Center, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
In rice, leucine-rich repeat nucleotide-binding site (NLR) proteins are pivotal immune receptors in combating -triggered rice blast. However, the precise molecular mechanism underlying how NLR proteins regulate downstream signalling remains elusive due to the lack of knowledge regarding their direct downstream targets. The NLR protein Pigm-1 was cloned from Shuangkang 77009 in our laboratory.
View Article and Find Full Text PDFEffects of Additional Flexible and Rigid Structure on BDT-BDD Terpolymer and the Performance of Organic Solar Cells.
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School of Materials Science and Engineering, Ocean University of China, Qingdao 266100, China.
In organic solar cells, the aggregation and crystallization of polymers are significant for bulk heterojunction. Blending with acceptor materials, polymer donor materials can adjust their aggregation by the movement of the chain segments. In this paper, the unfused structures based on thiophene and carbazole are respectively designed and introduced into the donor-acceptor copolymer donor materials to investigate the influence of flexible and rigid structures on polymer-aggregation leading photoelectric performance.
View Article and Find Full Text PDFBarriers to Blood Donation: Donor Deferrals in a Saudi Hospital Setting.
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Department of Clinical Laboratory Sciences, College of Applied Medical Sciences-Al-Qurayyat, Jouf University, Saudi Arabia.
Objective: Blood donation plays a critical role in healthcare systems by supplying blood and blood products for surgeries, emergency care, and chronic disease management. In Saudi Arabia, the prevalence of genetic disorders, like sickle cell disease and thalassemia, further increase the need for a stable blood supply. However, high rates of donor deferrals remain a significant barrier to maintaining a reliable blood supply.
View Article and Find Full Text PDFMicrobiome characterization of patients with Crohn disease and the use of fecal microbiota transplantation: A review.
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Department of Gastroenterology, The Second Affiliated Hospital of Hainan Medical University, Haikou, China.
Inflammatory bowel disease is a chronic inflammatory condition predominantly affecting the intestines, encompassing both ulcerative colitis and Crohn disease (CD). As one of the most common gastrointestinal disorders, CD's pathogenesis is closely linked with the intestinal microbiota. Recently, fecal microbiota transplantation (FMT) has gained attention as a potential treatment for CD, with the effective reestablishment of intestinal microecology considered a crucial mechanism of FMT therapy.
View Article and Find Full Text PDFTCR transgenic clone selection guided by immune receptor analysis and single-cell RNA expression of polyclonal responders.
Elife
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Laboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, Ghent, Belgium.
Since the precursor frequency of naive T cells is extremely low, investigating the early steps of antigen-specific T cell activation is challenging. To overcome this detection problem, adoptive transfer of a cohort of T cells purified from T cell receptor (TCR) transgenic donors has been extensively used but is not readily available for emerging pathogens. Constructing TCR transgenic mice from T cell hybridomas is a labor-intensive and sometimes erratic process, since the best clones are selected based on antigen-induced CD69 upregulation or IL-2 production in vitro, and TCR chains are polymerase chain reaction (PCR)-cloned into expression vectors.
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