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[Analysis of prescription rules for hyperlipidemia comorbid with hypertension based on latent structure model and association rules].
Zhongguo Zhong Yao Za Zhi
September 2024
Heart Center/National Regional (Traditional Chinese Medicine) Cardiovascular Diagnosis and Treatment Center, the First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450000, China.
Based on the latent structure model and association rule analysis, the regularity of prescription for hyperlipidemia comorbid with hypertension was explored, and traditional Chinese medicine(TCM) pattern type was speculated to provide a reference for clinical pattern differentiation and treatment, and guideline establishment. The literature on the treatment of hyperlipidemia comorbid with hypertension by TCM was systematically searched on CNKI, Wanfang, VIP, and SinoMed academic platforms. The relevant information was extracted and a database was established using Microsoft Excel 2019.
View Article and Find Full Text PDFASGR1 deficiency improves atherosclerosis but alters liver metabolism in ApoE mice.
Cardiovasc Diabetol
November 2024
Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Milan, Italy.
The asialoglycoprotein receptor 1 (ASGR1), a multivalent carbohydrate-binding receptor that primarily is responsible for recognizing and eliminating circulating glycoproteins with exposed galactose (Gal) or N-acetylgalactosamine (GalNAc) as terminal glycan residues, has been implicated in modulating the lipid metabolism and reducing cardiovascular disease burden. In this study, we investigated the impact of ASGR1 deficiency (ASGR1 on atherosclerosis by evaluating its effects on plaque formation, lipid metabolism, circulating immunoinflammatory response, and circulating N-glycome under the hypercholesterolemic condition in ApoE-deficient mice. After 16 weeks of a western-type diet, ApoE/ASGR1 mice presented lower plasma cholesterol and triglyceride levels compared to ApoE.
View Article and Find Full Text PDFClinical pharmacokinetics and pharmacodynamics of ongericimab: A potential long-acting PCSK9 monoclonal antibody in healthy subjects and patients with hypercholesterolemia: Randomized, double-blind, placebo-controlled phase Ia and Ib/II studies.
Clin Transl Sci
November 2024
Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) increases plasma low-density lipoprotein-cholesterol (LDL-C) by decreasing the expression of the LDL-receptor on hepatic cells. Ongericimab (JS002) is a novel PCSK9 monoclonal antibody that exhibits a long-acting LDL-C lowering effect by exclusively inhibiting PCSK9 in pre-clinical studies. Two randomized, double-blind, placebo-controlled trials were conducted to evaluate the safety, tolerability, efficacy, immunogenicity, pharmacokinetic, and pharmacodynamic profiles of ongericimab in healthy subjects and patients with hypercholesterolemia.
View Article and Find Full Text PDFUpdated Results from the Retrospective CREST Study on the Safety and Effectiveness of 8-Week Glecaprevir/Pibrentasvir in HCV-Infected Treatment-Naïve Patients with Compensated Cirrhosis.
Adv Ther
December 2024
AbbVie Inc., North Chicago, IL, USA.
Article Synopsis
- The study updates findings from the CREST study on the 8-week treatment of glecaprevir/pibrentasvir (GLE/PIB) for patients with chronic hepatitis C and compensated cirrhosis.
- It analyzes 437 patients, showing a high sustained virologic response (SVR12) of 98.9%, especially among those with certain comorbidities and those on other medications.
- The research highlights safety aspects, noting only a small percentage experienced adverse events, and emphasizes variations in healthcare resource use based on patients' employment status and drug use history.
Exploring Rosa roxburghii Tratt polysaccharides: From extraction to application potential in functional products - An in-depth review.
Int J Biol Macromol
September 2024
College of Medicine, Lijiang Culture and Tourism College, Lijiang 674100, China. Electronic address:
Article Synopsis
- - Rosa roxburghii Tratt (R. roxburghii) is a traditional medicinal and culinary plant from southwest China, known for its health benefits such as improving digestion, boosting immunity, and treating conditions like scurvy and hypertension.
- - The plant is rich in bioactive ingredients, particularly polysaccharides, which have various health-promoting properties, including antioxidant effects, anti-tumor activity, and immune modulation.
- - Despite the interest and research surrounding R. roxburghii and its polysaccharides, there is still a lack of comprehensive understanding regarding their chemical structure, mechanisms of action, and safety, which this research aims to address for better utilization.
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