The diagnostic problems of acute, unilateral exophthalmus are discussed in connection with a case of spontaneous intraorbital haematoma by the rupture of a venous saccular aneurysm.
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A Possible Phenotype-to-Genotype Association of Novel Single-Nucleotide Variants in the Coding Exons of the Gene to Arterial Aneurysmal and Dissection Diseases.
Int J Mol Sci
December 2024
Sathyamoorthy Laboratory, Department of Medicine, Burnett School of Medicine at TCU, Fort Worth, TX 76104, USA.
After reporting the first known clinical case associating compound heterozygous single-nucleotide variants in Exon 2 of to aortic aneurysmal and iliac dissection, we began prospective surveillance in our vascular genetic practice for similar cases. Herein, we present nine (9) subjects from a total cohort of 135 with arterial aneurysms or dissections who revealed single-nucleotide variants in with no other alterations in a panel of 35 genes associated with aneurysmal and dissection disorders. Five out of nine (5/9) single-nucleotide variants were in Exon 1, and four out of nine (4/9) mutations were in Exon 2, both of which are principal coding exons for this gene.
View Article and Find Full Text PDFOlfactory Receptors and Aortic Aneurysm: Review of Disease Pathways.
J Clin Med
December 2024
Department of Cardiothoracic Surgery, University General Hospital, Democritus University of Thrace, 68100 Alexandroupolis, Greece.
Aortic aneurysm, the pathological dilatation of the aorta at distinct locations, can be attributed to many different genetic and environmental factors. The resulting pathobiological disturbances generate a complex interplay of processes affecting cells and extracellular molecules of the tunica interna, media and externa. In short, aortic aneurysm can affect processes involving the extracellular matrix, lipid trafficking/atherosclerosis, vascular smooth muscle cells, inflammation, platelets and intraluminal thrombus formation, as well as various endothelial functions.
View Article and Find Full Text PDFEndovascular Repair of Spontaneous Rupture of Stent Graft Branch in Thoracoabdominal Aortic Aneurysm-Management, Case Study, and Review.
J Clin Med
December 2024
Department of Vascular Surgery and Transplantation, Medical University of Bialystok, 15-276 Bialystok, Poland.
Stent-graft implantation is a widely recognized method for endovascular treatment of aortic aneurysms. In cases where the aneurysm involves the thoracic and abdominal aorta, repair including fenestrated and branched stent grafts provides a viable alternative. This approach, initially reserved for patients unsuitable for open surgery, has become preferred for anatomically appropriate thoracoabdominal aortic aneurysms.
View Article and Find Full Text PDFResults of an Online Survey on Intensive Care Management of Patients with Aneurysmal Subarachnoid Hemorrhage in German-Speaking Countries.
J Clin Med
December 2024
Department of Neurology and Neurintensive Care Medicine, Academic Hospital Darmstadt, 64283 Darmstadt, Germany.
The clinical course of patients with aneurysmal SAH (aSAH) is often dynamic and highly unpredictable. Since its management varies between hospitals despite guidelines, this survey aimed to assess the current state of intensive care treatment for aSAH in the German-speaking region and provide insights that could aid standardization of care for aSAH patients in the intensive care setting. From February 2023 to April 2023, medical professionals of the German Interdisciplinary Association for Intensive Care and Emergency Medicine (DIVI), the Initiative of German Neuro-Intensive Trial Engagement (IGNITE) network and manually recorded clinics with intensive care units were invited to participate in a standardized anonymous online questionnaire including 44 questions.
View Article and Find Full Text PDFModeling and Visual Simulation of Bifurcation Aneurysms Using Smoothed Particle Hydrodynamics and Murray's Law.
Bioengineering (Basel)
November 2024
University of Electronic Science and Technology of China, Chengdu 611731, China.
Aneurysm modeling and simulation play an important role in many specialist areas in the field of medicine such as surgical education and training, clinical diagnosis and prediction, and treatment planning. Despite the considerable effort invested in developing computational fluid dynamics so far, visual simulation of blood flow dynamics in aneurysms, especially the under-explored aspect of bifurcation aneurysms, remains a challenging issue. To alleviate the situation, this study introduces a novel Smoothed Particle Hydrodynamics (SPH)-based method to model and visually simulate blood flow, bifurcation progression, and fluid-structure interaction.
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