Analysis of tolerance to physical load and blood lipid composition in 28 patients with the first clinical symptoms of coronary insufficiency and in 93 patients with cardialgia showed that diminished load tolerance with impaired induces of lipid metabolism is encountered more frequently (77.5%) than isolated hyperlipoproteinemia (15.2%) and low load tolerance without hyperlipoproteinemia (7.3%). In patients with low tolerance to load and hyperlipoproteinemia, the decrease of the threshold power and volume of work corresponds to the degree of disturbances in the blood lipid composition. The combination of cardialgia, hyperlipoproteinemia, and low load tolerance, manifested by tachycardia, may indicate that this is a case with ischemic heart disease.
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J Endocrinol Invest
January 2025
Department of Medicine (DIMED), University of Padova, Padua, Italy.
Purpose: A paradoxical increase in GH after oral glucose load (GH-Par) characterizes about one-third of acromegaly patients and is associated with a better response to first-generation somatostatin receptor ligands (fg-SRLs). Pasireotide is typically considered as a second-/third-line treatment. Here, we investigated the predictive role of GH-Par in pasireotide response and adverse event development.
View Article and Find Full Text PDFProc Biol Sci
January 2025
Department of Environmental and Life Sciences, Karlstad University, Karlstad 651 88, Sweden.
Recombination plays a key role in increasing the efficacy of selection. We investigate whether recombination can also play a role in resolving adaptive conflicts at loci coding for traits shared between the sexes. Errors during recombination events resulting in gene duplications may provide a long-term evolutionary advantage if those loci also experience sexually antagonistic (SA) selection since, after duplication, sex-specific expression profiles will be free to evolve, thereby reducing the load on population fitness and resolving the conflict.
View Article and Find Full Text PDFEndocr Pract
January 2025
Department of Nephrology, Shanghai Tenth People's Hospital, Shanghai, China. Electronic address:
Objectives: Fasting plasma glucose (FPG), glycated hemoglobin A (HbA), and 2-hour post-load plasma glucose (2h PG) are all currently used to define prediabetes. We aimed to determine whether a higher number of prediabetes defects corresponds to an increased all-cause and cardiovascular disease (CVD) mortality.
Methods: Individuals with prediabetes and available information on FPG, HbA, 2h PG, and mortality data were derived from the 2005 - 2016 National Health and Nutrition Examination Survey.
Sci Rep
January 2025
Department of the Environment, College of Basic Sciences, Hamedan Branch, Islamic Azad University, Hamedan, Iran.
In this study, the contamination, ecological and human health risks as well as source apportionment of As, Cd, Co, Cr, Cu, Mn, Ni, Pb, Zn, and V in street dusts of different land-uses in Kermanshah, Iran were investigated. A total of 192 dust samples were taken from 16 sites and were analyzed for their elemental contents using ICP-OES. The computed mean values for the geo-accumulation index (I-geo) and the pollution index (PI) ranged from - 6.
View Article and Find Full Text PDFInt J Food Microbiol
January 2025
Department of Food Science, Cornell University, Ithaca, NY 14853, United States.
Jellified materials were observed in spoiled pasteurized apple juice that contained dimethyl dicarbonate (DMDC). Microbiological analysis showed a high microbial load (4-5 log CFU/mL) in the sample. Acetobacter spp.
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