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Quantifying malaria endemicity in Ethiopia through combined application of classical methods and enzyme-linked immunosorbent assay: an initial step for countries with low transmission initiating elimination programme.
Malar J
April 2018
Department of Medical Laboratory Sciences and Pathology, Jimma University, Jimma, Ethiopia.
Background: In the context of reduced transmission of malaria, it is essential to re-evaluate and determine the level of transmission as it guides re-orientation of control measures which is appropriate to local disease epidemiology. However, little is known about level of malaria transmission in Ethiopia. The present study aimed to investigate the level of malaria transmission through combined application of classical methods and enzyme-linked immunosorbent assay (EIA) in low transmission settings of Ethiopia.
View Article and Find Full Text PDFEstimation on local transmission of malaria by serological approach under low transmission setting in Myanmar.
Malar J
January 2018
Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea.
Background: As the prevalence of the malaria has been decreasing in many endemic countries including Myanmar, malaria elimination in Greater Mekong Region was targeted not later than 2030. The relevance of molecular and serological tools to identify residual transmission remains to be established in this setting.
Methods: One-year cohort study was conducted and sera samples were collected in every 3 months with active and passive case detection for clinical malaria episodes by RDT, microscopy and molecular method.
Naturally acquired antibody response to Plasmodium falciparum describes heterogeneity in transmission on islands in Lake Victoria.
Sci Rep
August 2017
Island Malaria Group, Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, 17177, Sweden.
Article Synopsis
- The study examined anti-malaria antibody responses to identify differences in malaria transmission across various locations around Lake Victoria.
- Two surveys were conducted in January and August 2012, involving 4,112 participants whose blood samples were analyzed for malaria infection and antibody response.
- Findings revealed significant variations in antibody seroprevalence between the mainland, large island, and small islands, suggesting that these antibody metrics could be useful for understanding malaria exposure and guiding control efforts in endemic regions.
Relationship between exposure to malaria and haemoglobin level of children 2-9 years old in low malaria transmission settings.
Acta Trop
September 2017
Tropical and Infectious Diseases Research Center, Jimma University, Jimma, Ethiopia. Electronic address:
In the context of reduced transmission of malaria, it is essential to examine the association between exposure to malaria and haemoglobin level. This study measured the Haemoglobin level of children 2-9 years of age and examined its association with malariometric indices. A cross sectional study was conducted, during June 2016, on 763 children 2-9 years old, recruited from ten sites representing different malaria transmission settings in Ethiopia.
View Article and Find Full Text PDFContrasting Patterns of Serologic and Functional Antibody Dynamics to Plasmodium falciparum Antigens in a Kenyan Birth Cohort.
Clin Vaccine Immunol
February 2016
Center for Global Health and Diseases, Case Western Reserve University, Cleveland, Ohio, USA.
IgG antibodies to Plasmodium falciparum are transferred from the maternal to fetal circulation during pregnancy, wane after birth, and are subsequently acquired in response to natural infection. We examined the dynamics of malaria antibody responses of 84 Kenyan infants from birth to 36 months of age by (i) serology, (ii) variant surface antigen (VSA) assay, (iii) growth inhibitory activity (GIA), and (iv) invasion inhibition assays (IIA) specific for merozoite surface protein 1 (MSP1) and sialic acid-dependent invasion pathway. Maternal antibodies in each of these four categories were detected in cord blood and decreased to their lowest level by approximately 6 months of age.
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