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SRF and CBP jointly regulate integrin β6 overexpression in head and neck squamous cell carcinomas.
Cell Signal
January 2025
Department of Basic Medical Science & Department of Stomatology, School of Medicine, Xiamen University, Xiamen, Fujian, China. Electronic address:
Overexpression of integrin β6 (ITGB6) is crucially linked to the invasion and metastasis of head and neck squamous cell carcinoma (HNSCC). The molecular mechanisms driving ITGB6 upregulation in HNSCC are not well understood. Our study comprehensively analyzed the transcriptional regulation and epigenetic modification mechanisms affecting ITGB6 transcription.
View Article and Find Full Text PDFSidF, a dual substrate N5-acetyl-N5-hydroxy-L-ornithine transacetylase involved in siderophore biosynthesis.
J Struct Biol X
June 2025
Bioorganic Chemistry and Bio-Crystallography Laboratory (B2Cl) Faculty of Agricultural, Environmental and Food Sciences, Libera Università di Bolzano, Piazza Università, 1, 39100 Bolzano, Italy.
Siderophore-mediated iron acquisition is essential for the virulence of , a fungus causing life-threatening aspergillosis. Drugs targeting the siderophore biosynthetic pathway could help improve disease management. The transacetylases SidF and SidL generate intermediates for different siderophores in .
View Article and Find Full Text PDFComparative Study on Sedative and Hypnotic Effects of Crude and Parched Semen Ziziphi Spinosae: Integration of Network Pharmacology and In Vivo Pharmacological Evaluation.
Curr Comput Aided Drug Des
January 2025
Institute of Geriatrics, School of Basic Medicine, Hubei University of Chinese Medicine, Wuhan, 430065, China.
Objective: This study aimed to investigate the medicinal properties of SZS before and after processing and provide novel insights into its potential for treating insomnia.
Methods: This study employed the network pharmacology platform to gather information on the chemical composition of SZS, human targets, genes, molecular networks, and pathways associated with insomnia treatment using SZS. Liquid chromatography-tandem mass spectrometry (LC-MS/ MS) was utilized to analyze the chemical profiles of crude SZS, parched SZS, and their combined decoction.
The role of 1-Deoxysphingolipids and Polyamines in the pathogenesis of placental syndrome.
BMC Pregnancy Childbirth
January 2025
Department of Basic Pharmaceutical Sciences, Division of Biochemistry, Recep Tayyip Erdogan University, Rize, Turkey.
Background: Placental syndrome, mainly composed of preeclampsia and fetal growth restriction, has an impact on the health of mother and baby dyads. While impaired placentation is central to their pathophysiology, the underlying molecular mechanisms remain incompletely understood. This study investigates the association between placental syndrome and metabolic alterations in 1-deoxysphingolipids (1-deoxySLs) and polyamines, along with their regulatory enzymes.
View Article and Find Full Text PDFNovel inhibitors of the (VIBVN) NAT protein identified through pharmacophore modeling.
Sci Rep
January 2025
Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ministry of Education, Ocean University of China, Qingdao, 266071, China.
Arylamine N-acetyltransferases (NATs, E.C. 2.
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