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Pediatric pituitary adenomas (PPAs) are rare neoplasms with a propensity for unusual presentations and an aggressive clinical course. Here, the authors describe 6 highly atypical PPAs to highlight this tendency and discuss unexpected management challenges.A 14-year-old girl presented with acute hemiparesis and aphasia.
View Article and Find Full Text PDFMajor depletion of SOX2 stem cells in the adult pituitary is not restored which does not affect hormonal cell homeostasis and remodelling.
Sci Rep
December 2017
Department of Development and Regeneration, Cluster of Stem Cell and Developmental Biology (SCDB), Unit of Stem Cell Research, KU Leuven (University of Leuven), Leuven, Belgium.
The pituitary gland contains SOX2-expressing stem cells. However, their functional significance remains largely unmapped. We investigated their importance by depleting SOX2 cells through diphtheria toxin (DT)-mediated ablation.
View Article and Find Full Text PDFAdrenal obliteration by balloon-occluded retrograde venous ethanol injection in a swine model.
Minim Invasive Ther Allied Technol
December 2017
a Department of Radiology , Shiga University of Medical Science, Shiga , Japan.
Purpose: To evaluate the effects of adrenal obliteration by balloon-occluded retrograde venous ethanol injection.
Material And Methods: We inserted a micro-balloon catheter into the left adrenal vein of six pigs and retrogradely injected absolute ethanol (0.06 ml/kg) under balloon occlusion.
Hormonal effects on hamster lacrimal gland female-specific major 20 kDa secretory protein and its immunological similarity with submandibular gland major male-specific proteins.
J Steroid Biochem Mol Biol
January 2000
Centre for Cellular and Molecular Biology, Hyderabad, India.
Hormonal regulation of a major 20 kDa protein of hamster exorbital lacrimal gland (LG) was studied by SDS-PAGE profile analysis and the purified protein's antisera was used to screen tissues of hamster and other species for crossreacting proteins. This protein was seen in female LG but not in males and late-pregnant or hCG-treated females. Low estrogen state in females after gonadectomy, prolonged light-deprivation, prolonged starvation or lactation increased its level several folds to approximately 20% of LG soluble proteins and similar levels were induced in males after gonadectomy (low androgen state).
View Article and Find Full Text PDFGonadal and adrenal effects on hepatic epidermal growth factor receptor expression in a murine model.
Endocrinology
December 1991
Department of Obstetrics and Gynecology, Humana Hospital-Michael Reese, Chicago, Illinois 60616.
We hypothesize that the actions of epidermal growth factor (EGF) may be modulated by changes in cell surface EGF receptor (EGF-R) expression under endocrine influences. Mouse liver cell membrane preparations were used in a RRA. During ontogenesis, both sexes showed a significant increase (P less than 0.
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