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An integrative analysis reveals cancer risk associated with artificial sweeteners.
J Transl Med
January 2025
Medical College of YiChun University, Xuefu Road No 576, Yichun, 336000, Jiangxi, People's Republic of China.
Background: Artificial sweeteners (AS) have been widely utilized in the food, beverage, and pharmaceutical industries for decades. While numerous publications have suggested a potential link between AS and diseases, particularly cancer, controversy still surrounds this issue. This study aims to investigate the association between AS consumption and cancer risk.
View Article and Find Full Text PDFPharmacological activators of ALDH2: A new strategy for the treatment of alcohol use disorders.
Int Rev Neurobiol
November 2024
Department of Pharmacological and Toxicological Chemistry, Faculty of Chemical Sciences and Pharmacy, University of Chile, Santiago, Chile. Electronic address:
Article Synopsis
- * Despite its negative effects, acetaldehyde may also have rewarding properties in the brain, suggesting it plays a role in alcohol addiction.
- * The compound Alda-1 activates ALDH2, showing promise in animal studies for reducing alcohol consumption, preventing relapse, and protecting against alcohol-related tissue damage, indicating potential for treating alcohol use disorders.
Associations of saccharin intake with all-cause, cardiovascular and cancer mortality risk in USA adults.
Br J Nutr
November 2024
Zhejiang Provincial Center for Cardiovascular Disease Control and Prevention, Zhejiang Hospital, Hangzhou, People's Republic of China.
Article Synopsis
- Saccharin, a common sugar substitute, has uncertain long-term health effects, particularly on mortality related to cardiovascular disease (CVD) and cancer in diabetic and pre-diabetic, as well as overweight populations.
- The study found that higher saccharin intake was linked to increased risks of all-cause mortality (HR: 1.41), CVD mortality (HR: 1.93), and cancer mortality (HR: 2.26) in diabetic and pre-diabetic individuals, with even higher risks in overweight individuals (HR: 7.369 for cancer mortality).
- Substituting saccharin with total sugar or aspartame significantly lowered mortality rates, suggesting that reducing saccharin intake could improve
Exploring the Long-Term Effect of Artificial Sweeteners on Metabolic Health.
Cureus
September 2024
Department of Pharmacology, Sri Ramaswamy Memorial (SRM) College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, IND.
Artificial sweeteners (ASs) are widely used as low-calorie sugar substitutes for managing conditions like diabetes and obesity, but recent evidence suggests their health effects may be more complex than previously understood. High consumption has been associated with increased risks of metabolic disorders, cardiovascular diseases, certain cancers, and, somewhat paradoxically, weight gain, adverse pregnancy outcomes, and potential risks for individuals with low seizure thresholds. Studies, including the Women's Health Initiative, have linked artificially sweetened beverages to an elevated risk of stroke, coronary heart disease, and mortality, independent of established risk factors.
View Article and Find Full Text PDFMetabolomics signatures of sweetened beverages and added sugar are related to anthropometric measures of adiposity in young individuals: results from a cohort study.
Am J Clin Nutr
October 2024
Unit of Nutritional Epidemiology, Department of Nutrition and Food Sciences, University of Bonn, Bonn, Germany.
Background: The associations of sweetened beverages (SBs) and added sugar (AS) intake with adiposity are still debated. Metabolomics could provide insights into the mechanisms linking their intake to adiposity.
Objectives: We aimed to identify metabolomics biomarkers of intake of low- and no-calorie sweetened beverages (LNCSBs), sugar-sweetened beverages (SSBs), and ASs and to investigate their associations with body mass index, body fat percentage, and waist circumference.
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