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Extracting and analyzing micronuclei from mouse two-cell embryos fertilized with freeze-dried spermatozoa.
Commun Biol
January 2025
Faculty of Life and Environmental Sciences, University of Yamanashi, Yamanashi, Japan.
Abnormal chromosome segregation (ACS) in preimplantation embryos causes miscarriages. For a normal pregnancy, it is necessary to reduce ACS occurrences in embryos. However, the causes of such abnormalities are unclear because no method to extract the segregated chromosomes from the blastomeres for detailed analysis.
View Article and Find Full Text PDFChallenges and perspectives with understanding the concept of mental fatigue.
Int J Sports Med
January 2025
School of Exercise and Nutrition Sciences, Queensland University of Technology (QUT), Brisbane, Australia.
Mental fatigue is referred to as a psychophysiological or neurobiological state caused by prolonged periods of demanding cognitive activity. Sports and exercise science research have investigated the effects of experimentally induced mental fatigue on cognitive performance, with mixed results. It has been suggested that negative effects of mental fatigue on cognition performance in laboratory studies could translate to impaired sport performance.
View Article and Find Full Text PDFThe role of high-resolution cartilage thickness distribution for contact mechanics predictions in the tibiofemoral joint.
Proc Inst Mech Eng H
January 2025
Institute of Medical and Biological Engineering, University of Leeds, Leeds, UK.
Subject-specific finite element models of knee joint contact mechanics are used in assessment of interventions and disease states. Cartilage thickness distribution is one factor influencing the distribution of pressure. Precision of cartilage geometry capture varies between imaging protocols.
View Article and Find Full Text PDFFormulation Design, Optimization, and Evaluation of Solid Lipid Nanoparticles Loaded With an Antiviral Drug Tenofovir Using Box-Behnken Design for Boosting Oral Bioavailability.
Adv Pharmacol Pharm Sci
December 2024
Department of Pharmaceutics, SRM College of Pharmacy, SRMIST, Kattankulathur, Chennai, Tamil Nadu, India.
The current study aimed to improve the oral bioavailability of tenofovir (TNF), an antihuman immunodeficiency viral (HIV) drug, by integrating it into solid lipid nanoparticles (SLNs), an emerging lipid formulation. The suggested SLNs were generated utilizing the microemulsion process, using Compritol 888 ATO. A Box-Behnken experimental design was attempted to analyze the impact of critical quality attributes (CQAs), such as lipid and surfactant content and homogenization duration on response metrics such as particle size (PS) and percentage entrapment.
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