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Assessment of the Accuracy of Ultrasonographically Measured Optic Nerve Sheath Diameter as a Surrogate for the Detection of Intracranial Hypertension Compared to Optic Nerve Sheath Diameter Measured by MRI: A Prospective Observational Study.
Cureus
December 2024
Anaesthesiology and Critical Care, Postgraduate Institute of Medical Education and Research, Chandigarh, IND.
Background: Ultrasonographic measurement of optic nerve sheath diameter (ONSD) has been proposed as a non-invasive, bedside method to detect raised intracranial pressure (ICP) in various clinical settings. We aimed to correlate the ONSD obtained by ultrasonography (USG) with the ONSD obtained by magnetic resonance imaging (MRI) and to find its measurement accuracy.
Methodology: A prospective double-blind study was carried out by performing ocular ultrasounds on 32 patients with clinical features of intracranial hypertension.
In perennial allergic rhinitis, RQLQ is improved similarly by Azelastine 0.15 and mometasone furoate.
World Allergy Organ J
January 2025
Allergy & Asthma Solutions, Coto de Caza, CA, USA.
Unlabelled: Some double-blind, placebo-controlled trials have shown that Azelastine (Aze) high dose (0.15%) was effective in seasonal (SAR) and perennial allergic rhinitis (PAR). However, there was no long-term comparison between Aze 0.
View Article and Find Full Text PDFBackground: Transoral outlet reduction endoscopy (TORe) and glucagon-like peptide-1 agonist, liraglutide, have individually shown promise in managing weight regain after Roux-en-Y gastric bypass. However, combined effects of adjunctive liraglutide to TORe remain unexplored. A cross-over design was utilized to evaluate the efficacy of liraglutide treatment when initiated immediately post-TORe or 1 year post-TORe.
View Article and Find Full Text PDFHealth-related quality of life and symptoms in patients with previously untreated, locally advanced or metastatic non-squamous non-small cell lung cancer treated with sintilimab or placebo plus pemetrexed and platinum (ORIENT-11): A randomized, double-blind, phase 3 trial.
Lung Cancer
January 2025
Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou 510060, PR China. Electronic address:
Background: In the phase 3 ORIENT-11 study, sintilimab plus pemetrexed-platinum provided statistically significant longer overall survival and progression-free survival versus placebo plus pemetrexed-platinum as first-line treatment in patients with locally advanced or metastatic non-squamous non-small cell lung cancer (NSCLC). Here, we report the patient-reported outcomes (PRO) analysis findings in ORIENT-11.
Methods: PROs were measured using the European Organization for Research and Treatment of Cancer Quality of Life of Cancer Patients Questionnaire Core 30 items (EORTC QLQ-C30) and the Lung Cancer Symptom Scale (LCSS) questionnaire.
Effects of educational interventions for community pharmacists on promoting human papillomavirus vaccination: A randomized double-blind parallel group comparison trial.
Vaccine X
January 2025
Shinagawa Pharmaceutical Association, 2-4-2 Nakanobu, Shinagawa-ku, Tokyo 142-0053, Japan.
Objective: Owing to persistent concerns about side effects, human papillomavirus (HPV) vaccination rates in Japan have remained low. Pharmacists are therefore encouraged to improve vaccination rates by providing accurate information. This study evaluated the impact of educational interventions on pharmacists' knowledge and willingness to recommend the HPV vaccine.
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