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The impact of Daylight Saving Time on dog activity.
PLoS One
January 2025
Department of Anthropology, University of Toronto Mississauga, Mississauga, Ontario, Canada.
While most studies on Daylight Saving Time (DST) focus on human sleep and well-being, there is a dearth of understanding of how this sudden, human-mitigated change affects the routines of companion animals. The objective of this study was to assess how DST influenced the morning activity pattern of dogs (Canis familiaris). We used accelerometers to record activity in 25 sled dogs and 29 caregiver-companion dog dyads located in or near Ontario, Canada during the Fall Back time shift.
View Article and Find Full Text PDFObstructive Sleep Apnea, Circadian Rhythm Disturbance, Hypertension, and Kidney Stone: An Attractive Quadrangle? [Letter].
Nat Sci Sleep
January 2025
Department of Urology, Institute of Urology, West China Hospital, Chengdu, People's Republic of China.
Meta-analysis of retinal transcriptome profiling studies in animal models of myopia.
Front Med (Lausanne)
January 2025
Department of Ophthalmology, Emory University, Atlanta, GA, United States.
Objective: Myopia prevalence is increasing at alarming rates, yet the underlying mechanistic causes are not understood. Several studies have employed experimental animal models of myopia and transcriptome profiling to identify genes and pathways contributing to myopia. In this study, we determined the retinal transcriptome changes in response to form deprivation in mouse retinas.
View Article and Find Full Text PDFPre-treatment subjective sleep quality as a predictive biomarker of tDCS effects in preclinical Alzheimer's disease patients: Secondary analysis of a randomised clinical trial.
PLoS One
January 2025
Department of Psychiatry, The Chinese University of Hong Kong, Sha Tin, Hong Kong SAR, China.
Background: Despite transcranial direct current stimulation (tDCS) has demonstrated encouraging potential for modulating the circadian rhythm, little is known about how well and sustainably tDCS might improve the subjective sleep quality in older adults. This study sought to determine how tDCS affected sleep quality and cognition, as well as how well pre-treatment sleep quality predicted tDCS effects on domain-specific cognitive functions in patients with mild neurocognitive disorder due to Alzheimer's disease (NCD-AD).
Methods: This clinical trial aimed to compare the effectiveness of tDCS and cognitive training in mild NCD-AD patients (n = 201).
Comparative transcriptomic rhythms in the mouse and human prefrontal cortex.
Front Neurosci
January 2025
Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Introduction: Alterations in multiple subregions of the human prefrontal cortex (PFC) have been heavily implicated in psychiatric diseases. Moreover, emerging evidence suggests that circadian rhythms in gene expression are present across the brain, including in the PFC, and that these rhythms are altered in disease. However, investigation into the potential circadian mechanisms underlying these diseases in animal models must contend with the fact that the human PFC is highly evolved and specialized relative to that of rodents.
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