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The National Joint Registry Data Quality Audit of elbow arthroplasty.
Bone Joint J
December 2024
Nottingham University Hospitals NHS Trust, Nottingham, UK.
Article Synopsis
- The audit aimed to assess and improve the completeness and accuracy of the National Joint Registry (NJR) dataset specifically for elbow arthroplasty surgeries.
- In a two-phase approach, Phase 1 compared NJR data with NHS England Hospital Episode Statistics (HES), identifying thousands of unmatched and inaccurate records, particularly for radial head arthroplasties (RHAs).
- Phase 2 involved collaboration among 142 NHS hospitals to correct and update records, resulting in an improved completeness of the NJR dataset from 63% to 93% and accuracy from 94% to 98%.
Working ethics: William Beaumont, Alexis St. Martin, and medical research in antebellum America.
Bull Hist Med
September 2010
John Hopkins School of Medicine, MD, USA.
Analyzing William Beaumont's relationship with his experimental subject, Alexis St. Martin, this article demonstrates how the "research ethics" of antebellum America were predicated on models of employment, servitude, and labor. The association between Beaumont and St.
View Article and Find Full Text PDFHelicobacter pylori and peptic ulcer disease.
AJR Am J Roentgenol
February 1995
3C-31 GI Unit, San Francisco General Hospital, CA 94110.
Since William Beaumont's classic description of gastric physiology in 1847, the focus of clinical practice and basic research concerning gastric and duodenal ulcers has centered on the secretion of acid and pepsin. In addition to these well-known factors (largely determined by heredity, age, and oral intake), the search for other agents that alter the mucosal barrier has identified a bacillus, Helicobacter pylori, as a significant agent in the development of chronic gastritis and benign gastric and duodenal ulcers. This review explores the scientific evidence for an important causal role of H.
View Article and Find Full Text PDFBeaumont's contribution to gastric psychophysiology: a reappraisal.
Can J Psychiatry
October 1988
Department of Psychiatry, University of Ottawa, Ontario.
William Beaumont's monograph on the physiology of digestion which was first published in 1833, has become a classic in its field. In a series of experiments over a 10 year period on Alexis St. Martin, a 19 year old Canadian voyageur with a traumatic gastric fistula, Beaumont was the first to describe many important aspects of the digestive process.
View Article and Find Full Text PDFWilliam Beaumont's pioneering research on gastric secretion has been germinal in the discovery of proteolytic enzymes and the elucidation of their chemical structure, physiological roles, and biochemical evolution. Although the mammalian digestive enzymes, notably those of gastric and pancreatic origin, have been among the best characterized, of even greater interest and complexity are those that fulfill regulatory functions by limiting their action on specific peptide bonds in target protein substrates. The difference between digestive and regulatory proteases can best be understood by considering their evolutionary relationships on the basis of the organization of both their genes and the proteins themselves.
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