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Expression of osteogenic proteins in kidneys of cats with nephrocalcinosis.
J Vet Intern Med
January 2025
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota, USA.
Background: Nephrocalcinosis is a common pathological finding in cats with chronic kidney disease and nephrolithiasis. Understanding its pathogenesis may identify future therapeutic targets.
Hypothesis: Nephrocalcinosis is associated with expression of an osteogenic phenotype.
Advanced spectroscopic evidence for the sequestration of heavy metals via repetitive in situ synthesis of Fe oxide.
J Hazard Mater
January 2025
Department of Civil and Environmental Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea. Electronic address:
The in situ synthesis of Fe oxide is an established method for stabilizing metals and metalloids (Me) in contaminated soils. Nevertheless, the potential for enhanced Me sequestration through repeated Fe oxide application and the fundamental mechanisms of this process yet to be systemically investigated. In this study, the means by which repetitive Fe oxide synthesis enhances the immobilization of Cd, Zn, and As was investigated using batch experiments.
View Article and Find Full Text PDFPathogenic mechanisms of immune checkpoint inhibitor (ICI)-associated retinal and choroidal adverse reactions.
Am J Ophthalmol
January 2025
Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan, Ann Arbor, MI. Electronic address:
Purpose: To summarize and categorize postulated mechanisms of immune checkpoint inhibitor (ICI)-mediated retinal and choroidal inflammation and discuss resulting implications for evaluation and management of these adverse reactions.
Design: Targeted literature review with interpretation and perspective Methods: We performed a review of selected literature describing immune-mediated retinal and choroidal adverse reactions associated with ICI therapy, synthesizing and categorizing the likely underlying pathogenic mechanisms. Based on these mechanistic categories, we provide perspective on a rational approach to the evaluation of patients with ICI-associated inflammatory disorders of the retina and choroid.
Dermatologic Manifestations in Chronic Kidney Disease Patients.
Skinmed
January 2025
Department of Nephrology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.
Various specific and nonspecific dermatologic abnormalities are observed in chronic kidney disease (CKD). Dermatologic manifestations are observed at all stages of CKD and these increase with increasing duration and severity of the renal disease. Most of the studies in the literature have focussed mainly on dermatologic manifestations associated with dialysis and end-stage renal disease.
View Article and Find Full Text PDFThe snow must go on: how German cross-country skiers maintained training and performance in the face of COVID-19 lockdowns.
Front Sports Act Living
December 2024
Swedish Winter Sports Research Centre, Department of Health Sciences, Mid Sweden University, Östersund, Sweden.
Background: The Covid-19 pandemic in 2020 led to disruption of sporting events, with athletes obliged to comply with national lockdown restrictions.
Purpose: To investigate the effect of the Covid-19 pandemic restrictions on national-team XC skiers' annual and weekly training distribution from training diaries, results from submaximal and maximal physiological roller ski tests, and competition results from the International Ski and Snowboard Federation (FIS) world cup.
Methods: Annual and weekly training type (specific, non-specific, strength, other) and intensity distribution (TID) data were collected for 12 German XC-skiers (Tier 4/5; BM: 67 ± 7 kg; age 26 ± 3 years; 6♀: V̇O 61.
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