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DNA end sensing and cleavage by the Shedu anti-phage defense system.
Cell
December 2024
Department of Biochemistry, University of Zurich, Zurich, Switzerland. Electronic address:
The detection of molecular patterns associated with invading pathogens is a hallmark of innate immune systems. Prokaryotes deploy sophisticated host defense mechanisms in innate anti-phage immunity. Shedu is a single-component defense system comprising a putative nuclease SduA.
View Article and Find Full Text PDFAnti-viral defence by an mRNA ADP-ribosyltransferase that blocks translation.
Nature
December 2024
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
Host-pathogen conflicts are crucibles of molecular innovation. Selection for immunity to pathogens has driven the evolution of sophisticated immunity mechanisms throughout biology, including in bacterial defence against bacteriophages. Here we characterize the widely distributed anti-phage defence system CmdTAC, which provides robust defence against infection by the T-even family of phages.
View Article and Find Full Text PDFSporadic phage defense in epidemic mediated by the toxin-antitoxin system DarTG is countered by a phage-encoded antitoxin mimic.
mBio
October 2024
Department of Plant and Microbial Biology, University of California, Berkeley, California, USA.
Bacteria and their viral predators (phages) are constantly evolving to subvert one another. Many bacterial immune systems that inhibit phages are encoded on mobile genetic elements that can be horizontally transmitted to diverse bacteria. Despite the pervasive appearance of immune systems in bacteria, it is not often known if these immune systems function against phages that the host encounters in nature.
View Article and Find Full Text PDFRegulation of anti-phage defense mechanisms by using cinnamaldehyde as a quorum sensing inhibitor.
Front Microbiol
June 2024
Grupo de Microbiología Traslacional y Multidisciplinar (MicroTM)-Servicio de Microbiología Instituto de Investigación Biomédica A Coruña (INIBIC), Hospital A Coruña (CHUAC), Universidad de A Coruña (UDC), A Coruña, Spain.
Background: Multidrug-resistant bacteria and the shortage of new antibiotics constitute a serious health problem. This problem has led to increased interest in the use of bacteriophages, which have great potential as antimicrobial agents but also carry the risk of inducing resistance. The objective of the present study was to minimize the development of phage resistance in strains by inhibiting quorum sensing (QS) and thus demonstrate the role of QS in regulating defense mechanisms.
View Article and Find Full Text PDFNeutralizing antibodies after nebulized phage therapy in cystic fibrosis patients.
Med
September 2024
Institute for Integrative Systems Biology, University of Valencia-CSIC, 46980 Paterna, Spain. Electronic address:
Background: Cystic fibrosis (CF) patients are prone to recurrent multi-drug-resistant (MDR) bacterial lung infections. Under this scenario, phage therapy has been proposed as a promising tool. However, the limited number of reported cases hampers the understanding of clinical outcomes.
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