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Restraint stress effects on glutamate signaling protein levels in the rats' frontal cortex: Does β1 adrenoceptor activity matter?
Front Pharmacol
January 2025
Department of Brain Biochemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland.
Introduction: Stress-evoked dysfunctions of the frontal cortex (FC) are correlated with changes in the functioning of the glutamatergic system, and evidence demonstrates that noradrenergic transmission is an important regulator of this process. In the current study, we adopted a restraint stress (RS) model in male Wistar rats to investigate whether the blockade of β1 adrenergic receptors (β1AR) with betaxolol (BET) in stressed animals influences the body's stress response and the expression of selected signaling proteins in the medial prefrontal cortex (mPFC).
Methods: The study was divided into two parts.
Use of Physical Restraints for Patients with Hepatic Encephalopathy - Why We Should Restrain Our Enthusiasm.
Dig Dis Sci
January 2025
Leeds Liver Unit, St James's Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Exploring differences in reported mental health outcomes and quality of life between physically restrained and non-physically restrained ICU patients; a prospective cohort study.
Intensive Crit Care Nurs
January 2025
Radboud University Medical Center, Department of Intensive Care Medicine, PO Box 9101, 6500 HB Nijmegen, the Netherlands. Electronic address:
Background: Physical restraints are frequently used in ICU patients, while their effects are unclear.
Objective: To explore differences in patient reported mental health outcomes and quality of life between physical restrained and non-physical restrained ICU patients at 3- and 12-months post ICU admission, compared to pre-ICU health status.
Research Methodology/design: Prospective cohort study.
In vivo Feasibility of Arterial Embolization with a New Permanent Agar-Agar-Based Agent: Cause for Excitement and Restraint.
Cardiovasc Intervent Radiol
January 2025
Department of Radiology, Albany Medical Center, Albany, NY, 12208, USA.
Violence risk prediction in mental health inpatient settings using the Dynamic Appraisal of Situational Aggression.
Front Psychiatry
December 2024
Forensic Psychiatry Division, The Centre for Addiction and Mental Health, Toronto, ON, Canada.
Introduction/background: Aggression and violence are common problems in healthcare settings and affects both patients and healthcare staff. The Dynamic Appraisal of Situational Aggression (DASA) is an assessment tool to guide assessment for short term risk in inpatient settings. There have been no large-scale studies examining the performance of the DASA across different clinical settings.
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