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Concurrent versus sequential immunotherapy with chemoradiotherapy for unresectable stage III non-small-cell lung cancer: a retrospective study.
Front Oncol
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Department of Radiation Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Background: Immunotherapy combined with chemoradiotherapy has demonstrated promising efficacy in stage III non-small-cell lung cancer (NSCLC). However, the optimal timing for immunotherapy intervention during radiotherapy remains unclear. This study aimed to compare the efficacy and safety of immune checkpoint inhibitors (ICIs) administered concurrently or sequentially with chemoradiotherapy in unresectable stage III NSCLC.
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Heliyon
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Department of Computer Science and Engineering, Khulna University of Engineering & Technology, Khulna - 9203, Bangladesh.
Chemical industries are highly vulnerable to accidental events or terrorist attacks due to their processing, storage, and transportation of explosive, flammable, and toxic materials. Major industrial risks include fire, explosion, and toxic chemical release. An effective risk evaluation system is essential to prevent accidents or terrorist attacks.
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Environ Health (Wash)
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Department of Biology, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543, United States.
In May 2021, the M/V ship fire disaster led to the largest maritime spill of resin pellets (nurdles) and burnt plastic (pyroplastic). Field samples collected from beaches in Sri Lanka nearest to the ship comprised nurdles and pieces of pyroplastic. Three years later, the toxicity of the spilled material remains unresolved.
View Article and Find Full Text PDFNO-mediated DNA damage induced by polystyrene nanoparticles triggers program cell death in mesenchymal stem cells.
Drug Chem Toxicol
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Department of Genetics, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Daily contact with considerable amounts of polystyrene nanoparticles (PSNPs) may cause harmful effects on the living organisms, through mechanisms that are not fully understood. The study aimed to evaluate the cytotoxic and genotoxic effects of PSNPs (size 200 nm and 40 nm) in mesenchymal stem cells (MSCs). In order to estimate cellular uptake and retention of nanoplastics, PSNP-treated cells have been analyzed by transmission electron microscopy.
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J Hazard Mater
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College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China. Electronic address:
Biochar (BC) possesses diverse active sites (e.g., oxygen-containing groups OCGs, defects, and electronegative heteroatom) responsible for the catalytic reactions.
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