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Impact of adherence to quality indicators and effects of targeted treatment with cefazolin or flucloxacillin on in-hospital mortality in patients with methicillin-susceptible Staphylococcus aureus (MSSA) bloodstream infections: a retrospective observational study.
Infection
January 2025
Department of Infectious Diseases and Tropical Medicine, Hospital St. Georg, Leipzig, Germany.
Purpose: To analyze the associations between adherence to quality indicators (QIs) in the treatment of bloodstream infections caused by methicillin-susceptible Staphylococcus (S.) aureus (MSSA) and in-hospital mortality.
Methods: A retrospective observational study was conducted in patients admitted between 2019 and 2023 to Hospital St.
The risk of drug-induced liver injury associated with flucloxacillin: a nationwide, entropy-balanced cohort study.
Clin Microbiol Infect
December 2024
Division of Infection Medicine, Lund University, Lund, Sweden; Department of Infectious Diseases, Skåne University Hospital, Lund, Sweden.
Objectives: In this nationwide cohort study in a Scandinavian setting, we aimed to investigate the magnitude of association between flucloxacillin use and drug-induced liver injury (DILI).
Methods: Nationwide cohort study among adults in Sweden, 2006-2018, was conducted. Register data on filled prescriptions, patient characteristics, co-medications, and DILI were linked.
A 60-year-old polymorbid patient developed severe metabolic acidosis during weeks of treatment with flucloxacillin and paracetamol. The acidosis was triggered by an accumulation of 5-oxoproline due to pre-existing risk factors for glutathione deficiency as well as a ketoacidosis due to starvation. After treatment with N-acetylcysteine and hemofiltration, the acidosis completely resolved.
View Article and Find Full Text PDFTarget-controlled dialysis for antibiotics (TCD-ABx).
Intensive Care Med Exp
November 2024
Department of Anaesthesiology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
Article Synopsis
- * Five antibiotics were tested in an in vitro model of continuous veno-venous hemodialysis, simulating different patient scenarios to see how drug levels could be adjusted effectively during dialysis.
- * Results indicate that target-controlled dialysis can reliably adjust and maintain antibiotic concentrations at desired therapeutic levels throughout the treatment, suggesting it may improve patient outcomes in critical care settings.
Microbiological and Clinical Features of Patients with Cellulitis in Tropical Australia; Disease Severity Assessment and Implications for Clinical Management.
Am J Trop Med Hyg
November 2024
Department of Medicine, Cairns Hospital, Cairns, Australia.
Australian guidelines for the treatment of cellulitis are informed by data from temperate, metropolitan centers. It is uncertain if these guidelines are equally applicable in tropical Australia, where the population, access to healthcare, and array of potential pathogens are quite different. This retrospective study examined adults admitted to Cairns Hospital in tropical Queensland, Australia, who were treated with intravenous antibiotics for a principal diagnosis of cellulitis in 2019.
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