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Efficacy and safety of edaravone combined with Ginkgo Leaf Extract and Dipyridamole in the treatment of acute cerebral infarction: A systematic review and meta-analysis.
Medicine (Baltimore)
November 2024
Department of Neurology, The Second Affiliated Hospital of Zhejiang University of Chinese Medicine, Hangzhou, Zhejiang, China.
Background: To evaluate the clinical efficacy and safety of edaravone combined with Ginkgo Leaf Extract and Dipyridamole (GLED) versus edaravone alone in the treatment of acute cerebral infarction (ACI) by the method of meta-analysis.
Methods: PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure, WANFANG DATA, and Chinese Scientific Journal Database were searched to identify publications on edaravone combined with GLED for ACI from inception to June 20, 2024. Stata15.
Comparison of the Safety of Prednisone Plus Dipyridamole Versus Prednisone Plus Valsartan in the Treatment of Children with Primary Nephrotic Syndrome.
Iran J Kidney Dis
August 2024
Department of Pediatrics (No. 3 Ward), Northwest Women's and Children's Hospital, Xi'an, Shaanxi,710000, China.
Article Synopsis
- The study compares the effectiveness of two treatment combinations for pediatric nephrotic syndrome (NS): prednisone plus dipyridamole (Pred + DIP) and prednisone plus valsartan (Pred + VAL).
- Two hundred children with NS were divided into two groups, with results showing no significant differences in clinical efficacy or adverse reactions between treatments, but differences in coagulation and immune functions were noted.
- The findings suggest that while both treatments are effective, Pred + DIP enhances coagulation and immune functions, whereas Pred + VAL is better for reducing inflammation and managing blood lipid levels.
Reduction of Coronary Flow Velocity Reserve as the Main Driver of Prognostically Beneficial Coronary Revascularization.
J Am Soc Echocardiogr
January 2025
Cardiology Clinic, University Center Serbia, Medical School, University of Belgrade, Belgrade, Serbia.
Article Synopsis
- Regional wall motion abnormalities (RWMA) can be absent during stress echocardiography in patients with chronic coronary syndromes, even when coronary flow velocity reserve (CFVR) indicates significant disease.
- A study involving 749 patients showed that those with inducible RWMA had lower CFVR and that 69% underwent coronary revascularization, with 10-year survival rates significantly better in those treated invasively versus conservatively.
- The findings suggest a physiology-driven approach based on CFVR may be valuable for coronary revascularization decisions in patients with significant left anterior descending coronary artery disease.
Cumulative risk factors for flap failure, thrombosis, and hematoma in free flap reconstruction for head and neck cancer: a retrospective nested case-control study.
Int J Surg
December 2024
Master Program in Clinical Pharmacy, School of Pharmacy, College of Pharmacy, Kaohsiung Medical University.
Background: Free flap construction enhances the quality of life for head and neck cancer (HNC) patients; however, complications, such as thrombosis and hematoma, threaten flap survival. This study aimed to identify factors influencing flap failure, thrombosis, and hematoma.
Methods: A retrospective nested case-control study was conducted on HNC patients who underwent free flap reconstruction at a tertiary medical center between January 2019 and January 2022.
Updated Assessment of Practice Patterns of Perioperative Management of Antiplatelet and Anticoagulant Therapy in Interventional Pain Management.
Pain Physician
August 2024
Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Background: The role of antiplatelet/anticoagulant therapy is well known for its primary and secondary prevention of sequela from cardiovascular disease by decreasing the incidence of acute cerebral, cardiovascular, peripheral vascular, and other thrombo-embolicevents. The overwhelming data show that the risk of thrombotic events is significantly higher than that of bleeding during surgery after antiplatelet drug discontinuation. It has been assumed that discontinuing antiplatelet therapy prior to performing interventional pain management techniques is a common practice, even though doing so may potentially increase the risk of acute cerebral and cardiovascular events.
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