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Application of UPWr_E124 phage cocktail for effective reduction of avian pathogenic Escherichia coli in mice and broiler chickens.
Vet Microbiol
January 2025
Department of Biotechnology and Food Microbiology, Faculty of Biotechnology and Food Sciences, Wrocław University of Environmental and Life Sciences, 37 Chełmońskiego St., Wrocław 51-630, Poland. Electronic address:
Avian pathogenic Escherichia coli (APEC) is the main causative agent of colibacillosis, causing poultry respiratory infections, mortality and economic loss. APEC poses a serious threat to public health and food safety due to its multi-drug resistance and capacity to form biofilms. Bacteriophages (phages) have emerged as an alternative to antibiotics.
View Article and Find Full Text PDFTIR signaling activates caspase-like immunity in bacteria.
Science
January 2025
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Caspase family proteases and Toll/interleukin-1 receptor (TIR)-domain proteins have central roles in innate immunity and regulated cell death in humans. We describe a bacterial immune system comprising both a caspase-like protease and a TIR-domain protein. We found that the TIR protein, once it recognizes phage invasion, produces the previously unknown immune signaling molecule adenosine 5'-diphosphate-cyclo[N7:1'']-ribose (N7-cADPR).
View Article and Find Full Text PDFComparative Analysis of Spacer Targets in CRISPR-Cas Systems of Starter Cultures.
Acta Naturae
January 2024
Higher School of Economics, Faculty of Biology and Biotechnology, Moscow, 101000 Russian Federation.
Dairy production facilities represent a unique ecological niche for bacteriophages of lactic acid bacteria. Throughout evolution, bacteria have developed a wide range of defense mechanisms against viral infections caused by bacteriophages. The CRISPR-Cas system is of particular interest due to its adaptive nature.
View Article and Find Full Text PDFVisualization of Nucleic Acids in Microand Nanometer-Scale Biological Objects Using Analytical Electron Microscopy.
Acta Naturae
January 2024
Lomonosov Moscow State University, Faculty of Biology, Moscow, 119234 Russian Federation.
Analytical electron microscopy techniques, including energy-dispersive X-ray spectroscopy (EDX) and electron energy-loss spectroscopy (EELS), are employed in materials science and biology to visualize and chemically map diverse elements. This review presents cases of successful identification of nucleic acids in cells and in DNA- and RNA-containing viruses that use the chemical element phosphorus as a marker.
View Article and Find Full Text PDFsuperinfection drives Pf phage transmission within airway infections in patients with cystic fibrosis.
bioRxiv
January 2025
Center for Excellence in Pulmonary Biology, Division of Pulmonary Medicine, Department of Pediatrics, Stanford University, Stanford, CA, USA.
Pf bacteriophages, lysogenic viruses that infect , are implicated in the pathogenesis of chronic infections; phage-infected (Pf+) strains are known to predominate in people with cystic fibrosis (pwCF) who are older and have more severe disease. However, the transmission patterns of Pf underlying the progressive dominance of Pf+ strains are unclear. In particular, it is unknown whether phage transmission commonly occurs horizontally between bacteria within the airway via viral particles or if Pf+ bacteria are mostly acquired via new infections.
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