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Seronegative and Low Seropositive Treatment-Naive Secondary Syphilis in India: A Cross Sectional Study.
Indian J Dermatol
October 2024
From the Department of Dermatology, Venereology and Leprosy, KPC Medical College and Hospital, Kolkata, West Bengal, India.
The non-treponemal tests like VDRL and RPR hold an important place in the diagnosis of syphilis. In many countries, these tests are used for screening, with positive results being subsequently confirmed by treponemal or specific tests like TPHA or FTA-ABS. Recent observations of low-titer VDRL or RPR positivity (<1:8) or negative results in patients with clinically active syphilis are becoming a cause for concern especially in the backdrop of a resurgence of the disease.
View Article and Find Full Text PDFPerformance Assessment of Treponemal and Nontreponemal Tests for the Diagnosis of Acquired Syphilis.
Am J Trop Med Hyg
June 2024
Advanced Public Health Laboratory, Institute Gonçalo Moniz, Foundation Oswaldo Cruz (FIOCRUZ-BA), Salvador, Brazil.
There are a variety of nontreponemal test (NTT) and treponemal test (TT) kits for the serologic diagnosis of syphilis. Because of the complexity of the infection (multiple clinical stages) and the different antigens used in these kits, a systematic evaluation of the accuracy of the currently available commercial tests is warranted. Our objective was to evaluate the performance of commercially available tests for the diagnosis of syphilis infection.
View Article and Find Full Text PDFDeciphering the Great Imitator: Syphilis and Neurosyphilis.
Cureus
February 2024
Psychiatry, East Carolina University Health Medical Center, Greenville, USA.
Syphilis is an infectious disease caused by . Often known as the "great imitator," it has periods of active disease and periods of latency. Serologic syphilis testing can be divided into treponemal and non-treponemal tests, and multiple tests are required to prove infection.
View Article and Find Full Text PDFA thirty-eight year-old male presented with a seven-week history of persistent fever accompanied by recurrent night sweats, chills, arthralgias, headache, and chest tightness.Initial laboratory testing showed non-specific elevation of inflammatory markers, but was otherwise unremarkable.A palmar rash developed one week later, prompting testing for syphilis.
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