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Empathetic solicitude attenuates the affective and sensory dimensions of CO-induced dyspnea: A randomized parallel arm experimental trial in healthy humans.
Psychophysiology
December 2024
Sorbonne Université, INSERM, UMRS1158 Neurophysiologie Respiratoire Expérimentale et Clinique, Paris, France.
Dyspnea testifies to profound suffering in patients and its relief is a priority for caregivers. This can be achieved by correcting causative disorders ("etiopathogenic" approach) or targeting the dyspnea itself ("symptomatic" approach), as is done for pain. Empathetic solicitude from caregivers has an intrinsic analgesic effect, but its effects on dyspnea have not been formally documented.
View Article and Find Full Text PDFSupplemental oxygen for pulmonary embolism (SO-PE): study protocol for a mechanistic, randomised, blinded, cross-over study.
BMJ Open
November 2024
Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
Background: Acute pulmonary embolism (PE) mortality is linked to abrupt rises in pulmonary artery (PA) pressure due to mechanical obstruction and pulmonary vasoconstriction, leading to right ventricular (RV) dilation, increased RV wall tension and oxygen demand, but compromised right coronary artery oxygen supply. Oxygen is a known pulmonary vasodilator, and in preclinical animal models of PE, supplemental oxygen reduces PA pressures and improves RV function. However, the mechanisms driving these interactions, especially in humans, remain poorly understood.
View Article and Find Full Text PDFLow- and high-volume blood-flow restriction treadmill walking both improve maximal aerobic capacity independently of blood volume.
Scand J Med Sci Sports
January 2024
Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.
Aim: Assess the effect of low- and high-volume blood flow restriction training (BFR) on maximal aerobic capacity (VO max) and determine if alteration in VO max is mediated through changes in hemoglobin mass (Hbmass) and blood volume.
Methods: Participants' Hb (CO-rebreathe), single, and double-leg VO max and blood volume regulating hormonal responses (renin and copeptin) were measured before and after BFR training. Training consisted of treadmill walking either (1) twice-daily for 4week (CON and BFR ) or (2) twice-weekly for 6week (BFR ).
Helmet continuous positive airway pressure for patients' transport using a single oxygen cylinder: A bench study.
Pulmonology
October 2023
Department of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy; Department of Anesthesia and Intensive Care Medicine, Niguarda Ca' Granda, Milan, Italy.
Background: Continuous positive airway pressure (CPAP) is frequently used to treat patients with acute respiratory failure in out-of-hospital settings. Compared to a facemask, the helmet has many advantages for the patient but requires a minimum gas flow of 60 L/min to avoid CO rebreathing. The aim of the present bench study was to evaluate the performance of four Venturi devices, connected to a single oxygen cylinder, in delivering helmet-CPAP with clinically relevant gas flow, fraction of inspired oxygen (FiO) and positive end-expiratory pressure (PEEP) values.
View Article and Find Full Text PDFA test of the interaction between central and peripheral respiratory chemoreflexes in humans.
J Physiol
October 2023
School of Kinesiology, The University of Western Ontario, London, ON, Canada.
How central and peripheral chemoreceptor drives to breathe interact in humans remains contentious. We measured the peripheral chemoreflex sensitivity to hypoxia (PChS) at various isocapnic CO tensions ( ) to determine the form of the relationship between PChS and central . Twenty participants (10F) completed three repetitions of modified rebreathing tests with end-tidal ( ) clamped at 150, 70, 60 and 45 mmHg.
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