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Development and validation of the Women Autonomy Scale for measuring psychosocial freedom from conventional gender roles.
BMC Psychol
January 2025
Department of Psychiatry, College of Medicine and Health Sciences, Government Hospitals, Arabian Gulf University, Manama, Bahrain.
Background: The concepts of masculinity and femininity have historically shaped gender roles, leading to inequality and gender-based discrimination. Women's autonomy, defined as the ability to make independent choices across various life domains, remains inadequately measured by existing scales. This study addresses this gap by developing and validating the Women Autonomy Scale (WAS).
View Article and Find Full Text PDFIsolation of Natural Products Using Preparative TLC.
Methods Mol Biol
January 2025
Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, Republic of Korea.
Known for their diverse and potent physiological activities, natural products continue to be essential for the discovery and development of new drugs. This chapter explores the pivotal role of preparative thin-layer chromatography (Prep-TLC) in the isolation of natural products. This chapter begins with an understanding of the historical significance and structural complexity of natural products, and discusses the problems caused by complex mixtures present in extracts, as well as the multifunctionality, cost-effectiveness, and compatibility with different sample types of Prep-TLC to address these challenges.
View Article and Find Full Text PDFNatural Products Analysis Through Time: From Past Achievements to Future Prospects.
Methods Mol Biol
January 2025
Natural Products Lab, Institute of Biology, Leiden University, Leiden, The Netherlands.
This introductory chapter traces the evolution of (bio)chemical assays, emphasizing the critical role of robust protocols in ensuring reproducibility-a fundamental aspect of scientific research. With the advent of systems biology, the need for standardized methods has intensified, particularly for integrating vast datasets in open-access formats. The historical progression from basic plant morphology to advanced chromatographic and spectroscopic techniques in phytochemistry highlights the necessity for precise, reproducible protocols.
View Article and Find Full Text PDFHuman enteroid monolayers: A novel, functionally stable model for investigating oral drug disposition.
Drug Metab Dispos
January 2025
Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington. Electronic address:
To further the development of an in vitro model that faithfully recapitulates drug disposition of orally administered drugs, we investigated the utility of human enteroid monolayers to simultaneously assess intestinal drug absorption and first-pass metabolism processes. We cultured human enteroid monolayers from 3 donors, derived via biopsies containing duodenal stem cells that were propagated and then differentiated atop permeable Transwell inserts, and confirmed transformation into a largely enterocyte population via RNA sequencing analysis and immunocytochemistry (ICC) assays. Proper cell morphology was assessed and confirmed via bright field microscopy and ICC imaging of tight junction proteins and other apically and basolaterally localized proteins.
View Article and Find Full Text PDFSustainable Refinery Waste Management through Biotechnological Interventions: Health Impacts, Historical Successes, and Emerging Solutions.
Environ Res
January 2025
CSIR-North East Institute of Science and Technology, Jorhat-785006, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. Electronic address:
In today's highly competitive and interconnected global market, economic achievement and prosperity are essential needs for every individual. However, in recent years, the "science of sustainability" has gained popularity due to mounting evidence of the damaging impacts of environmental issues. Lately, the expansion of petroleum industries and refineries has led to a substantial rise in the production of refinery oily waste.
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