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Development and preliminary application of high-performance liquid chromatographic assay of urinary metabolites of diazepam in humans.
J Chromatogr B Biomed Appl
June 1995
Department of Clinical Pharmacology, International Medical Center of Japan, Tokyo.
A simple high-performance liquid chromatographic method for the measurement of diazepam (DZP) and its major metabolites, N-desmethyldiazepam (DMDZP), temazepam (TZP) and oxazepam (OZP) in urine was developed. Preliminary studies of DZP metabolism were also undertaken in four healthy volunteers after administration of a single oral dose (4 mg) of DZP. The assay allowed the simultaneous determination of all analytes in 1 ml of urine and the detection limit was 2 ng/ml with a signal-to-noise ratio of 3.
View Article and Find Full Text PDFSimultaneous high-performance liquid chromatography-electrochemical detection determination of imipramine, desipramine, their 2-hydroxylated metabolites, and imipramine N-oxide in human plasma and urine: preliminary application to oxidation pharmacogenetics.
Ther Drug Monit
June 1993
Division of Clinical Pharmacology, National Medical Center, Tokyo, Japan.
This assay method allows a simultaneous determination of imipramine, desipramine, their 2-hydroxylated metabolites, and imipramine-N-oxide in 0.5 ml of plasma or 0.1 ml of urine within 35 min by an ion-paired, reversed phase (C18) high-performance liquid chromatography (HPLC) with electrochemical detection.
View Article and Find Full Text PDFIn order to evaluate the anticholinergic effect of antidepressant drugs, 11 healthy volunteers were given single oral doses of reference drug, test drugs or placebo on a double-blind basis at weekly intervals. The doses corresponded to average daily patient medications. Spontaneous whole mouth and parotid salivation, and plasma levels of drug and possible metabolites were measured 2, 6 and 10 h after drug administration.
View Article and Find Full Text PDFCritical flicker fusion (CFF) test for sedative effect of antidepressants.
Acta Psychiatr Scand Suppl
June 1981
It is important to know in which direction and to what extent a drug affects cerebral arousal. Critical flicker fusion (CFF) is a most reliable method for measuring this particular quality of various drugs. A semi-automatic apparatus was used under standardized conditions, and double-blind technique was employed.
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