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Update to RIFM fragrance ingredient safety assessment, amyl alcohol, CAS Registry Number 71-41-0.
Food Chem Toxicol
December 2024
Research Institute for Fragrance Materials, Inc., 1200 MacArthur Boulevard, Suite 306, Mahwah, NJ, 07430, USA.
Pyrazine derivative synthesis in a continuous-flow system: a green synthesis of pyrazinamide from pyrazine esters and amines catalyzed by Lipozyme® TL IM from .
RSC Adv
December 2024
Zhejiang Provincial Key Laboratory of Chemical Utilization of Forestry Biomass, Zhejiang A&F University Zhejiang Hangzhou 311300 China.
Pyrazinamide derivatives have been extensively studied for their biological activities, such as anti-tuberculosis activity and antiviral activities. In this work, a continuous-flow system was developed for the synthesis of pyrazinamide derivatives from pyrazine esters and amines (aliphatic amine, benzylamines and morpholine) catalyzed by Lipozyme® TL IM from , which was used for the first time. The reaction parameters including solvent, substrate ratio, reaction temperature and reaction time/flow rate were also studied in detail.
View Article and Find Full Text PDFIncorporating New Datatypes to Enhance Species Delimitation: A Case Study in Rice Paddy Snakes (Homalopsidae: Hypsiscopus).
Zootaxa
August 2024
Section of Research & Collections; North Carolina Museum of Natural Sciences; North Carolina; 27601; USA.
Article Synopsis
- - Homalopsids, or Old World Mud Snakes, consist of 59 semiaquatic species across Asia and Australasia, showcasing various adaptations that make them important for evolutionary biology research.
- - Recent studies have doubled the recognized diversity of rice paddy snakes (Hypsiscopus), particularly revealing distinct lineages on either side of the Red River Basin in Vietnam, indicating a significant biogeographic barrier.
- - The study identified that populations west of the Red River Basin are a separate species called H. murphyi, while those to the east are linked to H. wettsteini, demonstrating the need for advanced methods in taxonomy to understand species evolution and distribution.
Renal manifestations of MGUS.
Hematology Am Soc Hematol Educ Program
December 2024
Department of Hematology and Cellular Therapy, Centre de référence maladies rares, Amylose AL et autres maladies par dépôts d'immunoglobulines monoclonales, Centre Hospitalier Universitaire Limoges, Université de Limoges, Limoges, France.
Kidney disease is a common complication of monoclonal immunoglobulin (MIg)-secreting B-cell disorders and predominantly occurs in patients who do not meet the criteria for an overt hematological disease. To distinguish this situation from monoclonal gammopathy of undetermined significance, which lacks organ damage, the term monoclonal gammopathy of renal significance (MGRS) was introduced to depict the association of a small, otherwise indolent B-cell clone, with renal disease induced by the secreted MIg. The spectrum of renal disorders in MGRS is wide, encompassing both tubular and glomerular disorders, classified according to the composition of deposits and their ultrastructural pattern of organization.
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