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Emergence of a bla-carrying extensively drug-resistant Enterobacter cloacae ST1718 in Saudi Arabia: Insights from comprehensive genome analysis.
J Infect Public Health
January 2025
Public health Laboratory, The regional laboratory, Jazan Health Cluster, Jazan, Saudi Arabia.
Background: Patients with severe COVID-19 may require intensive care unit (ICU) admission to manage life-threatening complications. However, ICU admission is associated with an increased risk of acquiring nosocomial infections caused by multidrug-resistant (MDR) bacteria, particularly carbapenem-resistant Enterobacterale (CRE). Enterobacter cloacae complex (ECC), a group of closely related species including Enterobacter cloacae, is a common cause of healthcare-associated infections (HAIs).
View Article and Find Full Text PDFExploring the antimicrobial potential of pomegranate peel extracts (PPEs): Extraction techniques and bacterial susceptibility.
PLoS One
December 2024
Faculty of Pharmacy, Department of Pharmaceutics and Pharmaceutical Science, Applied Science Private University, Amman, Jordan.
Antimicrobial resistance is increasing globally and is one of the major public health concerns. This highlights the need to search for new antimicrobial agents. Natural fruit by-products are a rich source of bioactive compounds.
View Article and Find Full Text PDFThe antimicrobial and antibiofilm effects of gentamicin, imipenem, and fucoidan combinations against dual-species biofilms of Staphylococcus aureus and Acinetobacter baumannii isolated from diabetic foot ulcers.
Ann Clin Microbiol Antimicrob
November 2024
Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
Introduction: Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to impaired insulin production or utilization, leading to severe health complications. Diabetic foot ulcers (DFUs) represent a major complication, often exacerbated by polymicrobial infections involving Staphylococcus aureus and Acinetobacter baumannii. These pathogens, notorious for their resistance to antibiotics, complicate treatment efforts, especially due to biofilm formation, which enhances bacterial survival and resistance.
View Article and Find Full Text PDFGlycodiversification of gentamicins through glycosyltransferase swapping enabled the creation of novel hybrid aminoglycoside antibiotics with potent activity and low ototoxicity.
Acta Pharm Sin B
September 2024
Department of Hematology, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
Aminoglycosides (AGs) are a class of antibiotics with a broad spectrum of activity. However, their use is limited by safety concerns associated with nephrotoxicity and ototoxicity, as well as drug resistance. To address these issues, semi-synthetic approaches for modifying natural AGs have generated new generations of AGs, however, with limited types of modification due to significant challenges in synthesis.
View Article and Find Full Text PDFGentamicin and clindamycin antibiotic-eluting depot technology eradicates in an implant-associated osteomyelitis pig model without systemic antibiotics.
Antimicrob Agents Chemother
October 2024
Department of Health Technology, Technical University of Denmark, Kgs. Lyngby, Denmark.
The therapeutic challenges of orthopedic device-related infections and emerging antimicrobial resistance have attracted attention to drug delivery technologies. This study evaluates the preclinical efficacy of local single- and dual-antibiotic therapy against implant-associated osteomyelitis (IAO) using a drug-eluting depot technology, CarboCell, that provides sustained release of high-dose antibiotics and allows for strategic placement in relation to infectious lesions. Clindamycin and gentamicin were formulated in CarboCell compositions.
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