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Cancers of the brain and central nervous system: global patterns and trends in incidence.
J Neurooncol
January 2025
Cancer Surveillance Branch, International Agency for Research On Cancer (IARC), 25 Avenue Tony Garnier, CS 90627, 69366 LYON CEDEX 07, Lyon, France.
Background: Global comparisons of the burden and impact of cancers of the brain and central nervous system (CNS) are critical for developing effective control strategies and generating etiological hypotheses to drive future research.
Methods: National incidence estimates were obtained from GLOBOCAN 2022, and recorded incidence data from the Cancer in Five Continents series, both developed and compiled by the International Agency for Research on Cancer. We examined the estimated age-standardized incidence rates in 185 countries, as well as time trends in recorded incidence in 35 countries, quantifying the direction and change in the magnitude of the rates using the estimated average percentage change (EAPC).
Prediction of dry matter intake in growing Black Bengal goats using artificial neural networks.
Trop Anim Health Prod
January 2025
Livestock Production and Management Section, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, 243 122, India.
Dry matter intake (DMI) determination is essential for effective management of meat goats, especially in optimizing feed utilization and production efficiency. Unfortunately, farmers often face challenges in accurately predicting DMI which leads to wastage of feed and an increase in the cost of production. This investigation aimed to predict DMI in Black Bengal goats by using body weight (BW), body condition score (BCS), average daily gain (ADG), and metabolic body weight (MBW) by applying an artificial neural network (ANN) model.
View Article and Find Full Text PDFAnti-PD-L1 envafolimab combined with anti-VEGF suvemcitug in pretreated solid tumors and hepatocellular carcinoma: an open-label phase II study with safety run-in stage.
Invest New Drugs
January 2025
Department of Internal Medicine, Jilin Cancer Hospital, Changchun, China.
Background: Immune checkpoint inhibitors (ICIs) combined with anti-vascular endothelial growth factor (VEGF) have been the standard first-line treatment of hepatocellular carcinoma (HCC). However, the efficacy of this combination in post-line treatment is still unknown. This study aimed to evaluate the efficacy and safety of the combination of anti-PD-L1 envafolimab and novel humanized anti-VEGF suvemcitug as second-line treatment for patients with HCC.
View Article and Find Full Text PDFCrude Antibiotics and Antifungal Metabolites from Chaetomium globosum Cg6 Suppress Pythium aphanidermatum, Causal Agent of Rhizome Rot of Turmeric.
Curr Microbiol
January 2025
Department of Plant Pathology, Tamil Nadu Agricultural University, Coimbatore, Tamil Nadu, 641003, India.
Turmeric is affected by various phytopathogens, which cause huge economic losses to farmers. In the present study, ten isolates of Pythium spp. were isolated from infected turmeric rhizomes and characterized.
View Article and Find Full Text PDFAlpelisib is a phosphatidylinositol 3-kinase inhibitor approved by the US Food and Drug Administration for the treatment of hormone receptor-positive metastatic breast cancer with (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α) mutation. In recent years a number of adverse effects have been observed to be associated with this therapy, the most notable of which is hyperglycemia. A literature search was conducted to include case studies, case series, systematic reviews, and meta-analyses within the last 10 years that evaluated patients with mutated hormone receptor-positive, human epidermal growth factor receptor 2 negative metastatic breast cancer.
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