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Genetic diversity of the immunoglobulin heavy chain locus in cohorts of patients affected with SARS-CoV-2.
Hum Genomics
January 2025
Department of Biology, Tor Vergata University of Rome, Via della Ricerca Scientifica 1, 00133, Rome, Italy.
Background: The Immunoglobulin Heavy Chain (IGH) genomic region is responsible for the production of circulating antibodies and warrants careful investigation for its association with COVID-19 characteristics. Multiple allelic variants within and across different IGH gene segments form a limited set of haplotypes. Previous studies have shown associations between some of these haplotypes and clinical outcomes of COVID-19.
View Article and Find Full Text PDFHospital in-reach family-centred social prescribing pilot for children with neurodisability: mixed methods evaluation with social return on investment analysis.
BMC Health Serv Res
January 2025
Population Health Sciences Institute, Newcastle University, Level 3, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK.
Background: Social prescribing link workers support individuals to engage with community resources, co-creating achievable goals. Most schemes are community-based, targetting adults. Vulnerable populations including hospitalized children with neurodisability and their families, could also benefit from social prescribing.
View Article and Find Full Text PDFTargeting ABCD1-ACOX1-MET/IGF1R axis suppresses multiple myeloma.
Leukemia
January 2025
Department of Pathology, Duke University School of Medicine, Durham, NC, 27710, USA.
Multiple myeloma (MM) remains an incurable hematological malignancy that necessitates the identification of novel therapeutic strategies. Here, we report that intracellular levels of very long chain fatty acids (VLCFAs) control the cytotoxicity of MM chemotherapeutic agents. Inhibition of VLCFA biosynthesis reduced cell death in MM cells caused by the proteasome inhibitor, bortezomib.
View Article and Find Full Text PDFAmbient ozone exposure and pregnancy complications and adverse birth outcomes: a systematic review and meta-analysis.
Environ Res
January 2025
Vanke School of Public Health, Tsinghua University, Beijing, China.
Background: Ambient ozone pollution is becoming a global health threat under global warming. Evidence on the association between ambient ozone and pregnancy complications and adverse birth outcomes has grown enormously. To provide a comprehensive assessment of the evidence, we performed a systematic review and meta-analysis to outline current epidemiological evidence.
View Article and Find Full Text PDFFood insecurity coping strategies in conflict affected areas of Northeastern Ethiopia.
Appetite
January 2025
Department of Geography and Environmental studies, Bahir Dar University, Bahir Dar, Ethiopia. Electronic address:
Albeit various factors are responsible for the rise of food insecurity and hunger at the global level, conflict has been identified as a key driver. The recurrent conflict in most developing countries leaves food insecurity a serious concern. Though little is known, the fact that many households in the conflict-affected areas are considered to be food insecure raises the question of how these households survive conflict-induced food insecurity.
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