Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Management of Mycosis Fungoides and Sézary Syndrome With Oral Systemic Therapies.
J Cutan Med Surg
March 2025
Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Mycosis fungoides (MF) and Sézary syndrome (SS) are subtypes of cutaneous T-cell lymphoma with numerous topical and systemic therapies. Early-stage MF can be managed with topical corticosteroids, mechlorethamine, and phototherapy. However, patients are often non-responsive to topical therapies, thus requiring systemic therapies.
View Article and Find Full Text PDFMechanistic Insights and Pharmacological Approaches for Nitrogen and Sulfur Mustards and Their Implications as Therapeutic Agents.
J Appl Toxicol
March 2025
Department of Pharmacology and Toxicology, Boonshoft School of Medicine, Wright State University, Dayton, Ohio, USA.
Nitrogen and sulfur mustards, often acting as vesicants, have significant consequences for public health. Skin is a common site for exposure to these vesicants that can result in considerable morbidity and mortality. Given that the treatment options are limited, new insights into the mechanisms for the toxicity of these vesicants that can be translated into preventative/therapeutic strategies are desperately needed.
View Article and Find Full Text PDFBuprenorphine blunts inflammatory response and wound progression after skin exposure to nitrogen mustard.
Wound Repair Regen
March 2025
Center for Wound Healing and Tissue Regeneration, Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.
Opioid analgesics are often used to alleviate pain in rodent models of skin wound injury and repair. However, previous studies have demonstrated that opioids can alter the inflammatory response to injury and subsequent wound healing. The purpose of this study was to determine the impact of different formulations of buprenorphine on mouse behaviour, inflammatory response and wound progression following skin exposure to nitrogen mustard (NM).
View Article and Find Full Text PDFSecondary Cutaneous Malignancies Associated with Topical Chlormethine in Cutaneous T-Cell Lymphoma: A Systematic Review.
J Cutan Med Surg
February 2025
Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada.
Acute exposure to nitrogen mustard induces rapid nuclear component regulation and delayed stress to exogenous stimuli.
Int Immunopharmacol
February 2025
Clinical and Public Health Research Center, Women and Children's Hospital of Chongqing Medical University, Chongqing, China; Chongqing Health Center for Women and Children, Chongqing, China; Chongqing Research Center for Prevention & Control of Matermal and Child Disease and Public Health, Chongqing, China. Electronic address:
Nitrogen mustard (NM) is a vesicant agent with potent toxic effects on various tissues. Numerous theories have been proposed to explain its toxic mechanisms, yet research on the interconnections among these theories is lacking. This study focuses on analyzing the characteristics of genes involved in NM-induced bronchial injury within the Comparative Toxicogenomics Database (CTD).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!