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A randomized, placebo-controlled, cross-over trial of ketamine in Rett syndrome.
J Neurodev Disord
January 2025
Rett Syndrome Research Trust, Trumbull, CT, USA.
Background: Preclinical studies and anecdotal case reports support the potential therapeutic benefit of low-dose oral ketamine as a treatment of clinical symptoms in Rett syndrome (RTT); however, no controlled studies have been conducted in RTT to evaluate safety, tolerability and efficacy.
Design: This was a sequentially initiated, dose-escalating cohort, placebo-controlled, double blind, randomized sequence, cross-over study of oral ketamine in 6-12-year-old girls with RTT to evaluate short-term safety and tolerability and explore efficacy.
Methods: Participants were randomized to either five days treatment with oral ketamine or matched placebo, followed by a nine-day wash-out period and then crossed-over to the opposite treatment.
Do you have depression? A summative content analysis of mental health-related content on TikTok.
Digit Health
January 2025
Department of Occupational Science and Occupational Therapy, University of British Columbia, Vancouver, BC, Canada.
Background: TikTok is a global social media platform with over 1 billion active users. Presently, there are few data on how TikTok users navigate the platform for mental health purposes and the content they view.
Objective: This study aims to understand the patterns of mental health-related content on TikTok and assesses the accuracy and quality of the advice and information provided.
Tannin additions decrease the concentration of malodorous volatile sulfur compounds in wine-like model solutions and wine.
Food Chem
January 2025
Departamento de Horticultura, Facultad de Ciencias Agrarias, Universidad de Talca, 2 Norte 685, Talca, Chile.
Hydrogen sulfide (HS), methanethiol (MeSH) and ethanethiol (EtSH) are volatile sulfur compounds (VSCs) produced during winemaking and are associated with negative 'reductive' aromas in wine. Anecdotal evidence suggests that oenological tannins may be used to remediate the 'reductive' character of wines, yet little scientific evidence or explanation supporting this observation has been published. In this study, it was found that the addition of oenological tannins significantly decreased HS, MeSH, and EtSH in model wine by up to 92 %, 90 % and 86 %, respectively, after two weeks of storage.
View Article and Find Full Text PDFFournier's gangrene is a grave necrotizing fasciitis that primarily affects the perineum, spreading through the fascias and leading to significant tissue destruction. The involvement of the urethra in necrosis is extremely rare, if not anecdotal. Emphysematous pyelonephritis, is a urinary infection with a high risk of progression to sepsis.
View Article and Find Full Text PDFSuccessful Ex Situ Reduction During Hypothermic Oxygenated Machine Perfusion in a Severely Steatotic Graft From a Donor After Brain Death: An Anecdote?
Exp Clin Transplant
December 2024
>From the Department of Hepatobiliary and Pancreatic Surgery and Liver Transplantation, Vall d'Hebron Hospital, Barcelona, Spain.
Marginal liver grafts, such as those from cardiac death donors and donors with steatotic organs, are highly vulnerable to ischemia-reperfusion injury. In addition, ex situ graft alteration, either by reduction or splitting, will prolong the static cold storage time and amplify the ischemia-reperfusion injury. Hypothermic oxygenated machine perfusion has the potential to end the oxygen deprivation during preservation and accordingly improve outcomes in some marginal grafts that have been traditionally discarded.
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