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Metabolic pathways of eicosanoids-derivatives of arachidonic acid and their significance in skin.
Cell Mol Biol Lett
January 2025
Department of Analytical Chemistry, Medical University of Bialystok, Kilinskiego 1, 15-069, Bialystok, Poland.
The skin is a barrier that protects the human body against environmental factors (physical, including solar radiation, chemicals, and pathogens). The integrity and, consequently, the effective metabolic activity of skin cells is ensured by the cell membrane, the important structural and metabolic elements of which are phospholipids. Phospholipids are subject to continuous transformation, including enzymatic hydrolysis (with the participation of phospholipases A, C, and D) to free polyunsaturated fatty acids (PUFAs), which under the influence of cyclooxygenases (COX1/2), lipoxygenases (LOXs), and cytochrome P450 (CYPs P450) are metabolized to various classes of oxylipins, depending on the type of PUFA being metabolized and the enzyme acting.
View Article and Find Full Text PDFRepresentative Training Data Sets Are Critical for Accurate Machine-Learning Classification of Microscopy Images of Particles Formed by Lipase-catalyzed Polysorbate Hydrolysis.
J Pharm Sci
January 2025
Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, Colorado 80303. Electronic address:
Polysorbate 20 (PS20) is commonly used as an excipient in therapeutic protein formulations. However, over the course of a therapeutic protein product's shelf life, minute amounts of co-purified host-cell lipases may cause slow hydrolysis of PS20, releasing fatty acids (FAs). These FAs may precipitate to form subvisible particles that can be detected and imaged by various techniques, e.
View Article and Find Full Text PDFPreparation and characterization of a rat uterine decellularized scaffold.
Gland Surg
December 2024
Department of Gynecology, Wenzhou People's Hospital, Wenzhou, China.
Background: Infertility is a special reproductive health defect. For women, congenital uterine malformations, extensive adhesions in the uterine cavity, and hysterectomy are associated with infertility. Uterine transplantation is technically feasible, but its clinical application and development are limited by donor shortages and immune rejection.
View Article and Find Full Text PDFPreparation, characterization, and prebiotic potential of resistant maltodextrin from the remaining starch in cassava pulp.
Int J Biol Macromol
January 2025
Division of Biochemical Technology, School of Bioresources and Technology, King Mongkut's University of Technology Thonburi (Bangkhunthian Campus), Bangkok 10150, Thailand. Electronic address:
This study aimed to produce a novel resistant maltodextrin (RMD) from the remaining starch in cassava pulp via pyrodextrinization and enzymatic hydrolysis. The optimum conditions involved a temperature of 180 °C, 0.5 % HCl, and a reaction time of 5 h, resulting in a significant RMD yield (18.
View Article and Find Full Text PDFSurface Treatment of Polyamide 6 through Enzymatic Hydrolysis and Covalent Incorporation of Chitosan Nanoparticles.
Biomacromolecules
January 2025
Departamento de Química, Federal University of Santa Catarina, Roberto Sampaio Gonzaga Street, 88040-380 Florianópolis, Brazil.
Polyamide (PA) has notable physical and chemical properties and is one of the most versatile synthetic materials in the industrial sector. However, its hydrophobicity creates significant challenges in its beneficiation and modification. Modifications of PA with chitosan nanoparticles (CNPs) can improve its undesired properties but are rarely found in the literature due to the weak interaction between the chemical groups of both structures.
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