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Determination of the upper limit of normal for serum anti-streptolysin-O titre in primary school children in Southern Nigeria; A model for other low resource settings.
Int J Cardiol Cardiovasc Risk Prev
June 2024
Department of Child Health, University of Benin Teaching Hospital, PMB 1111, Benin City, Nigeria.
The prevention and treatment of Rheumatic Heart disease is hinged on antibiotic administration in children with Group A (GAS) pharyngitis and Acute Rheumatic Fever (ARF). The Upper Limit of Normal (ULN) for serum Anti-streptolysin O titre (ASOT) has been employed as proof of antecedent GAS pharyngitis to fulfil the Jones' criteria for diagnosis of ARF. This value has not been generated among West African children.
View Article and Find Full Text PDFChanges in renal function and morphological variations of kidney diseases in rheumatoid arthritis patients.
Asian J Urol
April 2024
Department of Hospital Therapy No. 1, I. M. Sechenov First Moscow State Medical University of Ministry of Health of Russian Federation (Sechenov University), Moscow, Russian Federation.
Objective: Rheumatoid nephropathy is one of the most severe extra-articular manifestations of rheumatoid arthritis (RA) associated with a very unfavorable prognosis. This study aimed to identify changes in renal function and morphological variations of kidney diseases in RA patients.
Methods: The study enrolled patients (126 patients) between 18 and 55 years of age with a confirmed active RA of more than 12 months.
Clinical profile of children with acute post-streptococcal glomerulonephritis.
Pediatr Nephrol
October 2023
Department of Pediatrics, KIST Medical College and Teaching Hospital, Imadol, Lalitpur, Nepal.
Background: Acute post-streptococcal glomerulonephritis (APSGN) is common in developing countries with a high hospitalization rate. Most patients have acute nephritic syndrome features, although some occasionally present with unusual clinical features. This study aims to describe and analyze clinical features, complications, and laboratory parameters in children diagnosed with APSGN at presentation, 4 and 12 weeks later, in a resource-limited setting.
View Article and Find Full Text PDFRole of streptococcal infection in the etiopathogenesis of pityriasis lichenoides chronica and the therapeutic efficacy of azithromycin: a randomized controlled trial.
Arch Dermatol Res
April 2023
Dermatology Department, Kasr Alainy Faculty of Medicine, Cairo University, Kasr Al Ainy St, Cairo, 11562, Egypt.
The exact aetiology of pityriasis lichenoides chronica (PLC) remains unknown. While phototherapy is the most investigated therapeutic modality, azithromycin has been used scarcely. The aim of this study is to evaluate the therapeutic efficacy of azithromycin in the treatment of PLC compared to NB-UVB and evaluating the presence of streptococcal infection as a possible etiological factor in PLC patients.
View Article and Find Full Text PDFLong-Term Prognostic Factors in Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A 15-Year Multicenter Retrospective Study.
Front Immunol
July 2022
Department of Rheumatology and Immunology, Affiliated Hospital of Guilin Medical University, Guilin, China.
Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a multisystem autoimmune disease with small-vessel involvement. In AAV, microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) are major clinicopathologic variants. In addition, myeloperoxidase (MPO) and proteinase 3 (PR3) are major target antigens.
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