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GhWRKY207 improves drought tolerance through promoting the expression of GhCSD3 and GhFSD2 in Gossypium hirsutum.
Plant Sci
January 2025
National Key Laboratory of Cotton Bio-breeding and Integrated Utilization, School of Life Sciences, College of Agriculture, Henan University, Kaifeng 475004, China. Electronic address:
Tryptophan-arginine-lysine-tyrosine (WRKY) transcription factors are essential regulators of drought tolerance in multiple plants. However, whether and how GhWRKY207 modulates cotton response to drought stress is unclear. In this study, we determined that GhWRKY207 expression was high in leaves and induced by drought stress.
View Article and Find Full Text PDFPhotochemical and Collision-Induced Cross-Linking of Lys, Arg, and His to Nitrile Imines in Peptide Conjugate Ions in the Gas Phase.
J Am Soc Mass Spectrom
January 2025
Department of Chemistry, Bagley Hall, Box 351700, University of Washington, Seattle, Washington 98195-1700, United States.
We report a study of internal covalent cross-linking with photolytically generated diarylnitrile imines of N-terminal arginine, lysine, and histidine residues in peptide conjugates. Conjugates in which a 4-(2-phenyltetrazol-5-yl)benzoyl group was attached to C-terminal lysine, that we call RAAA--K, KAAA--K, and HAAA--K, were ionized by electrospray and subjected to UV photodissociation (UVPD) at 213 nm. UVPD triggered loss of N and proceeded by covalent cross-linking to nitrile imine intermediates that involved the side chains of N-terminal arginine, lysine, and histidine, as well as the peptide amide groups.
View Article and Find Full Text PDFInsights into the pharmaceutical properties and in silico study of novel hydrazone derivatives.
Sci Rep
December 2024
Department of Animal Production, College of Food and Agriculture Sciences, King Saud University, Riyadh, 11451, Saudi Arabia.
It has been established that the Hydrazone derivatives have important pharmacological effects. In the first step, hydrazine (NHNH) reacts with a compound containing a carbonyl group (C = O) in the presence of ethanol and heat, leading to the formation of hydrazone compound (H1). The second step is the formation of the Schiff base (H2) by the reaction of compound (H1) with indole, ethanol, and acetic acid, which contain a double bond (C = N).
View Article and Find Full Text PDFThree Is a Magic Number: Tailored Clickable Chelators Used to Determine Optimal RGD-Peptide Multiplicity in αvβ6-Integrin Targeted Lu-Labeled Cancer Theranostics.
Bioconjug Chem
December 2024
TRIMT GmbH, Carl-Eschebach-Str. 7, 01454 Radeberg, Germany.
The cellular adhesion receptor αvβ6-integrin is highly expressed in many cancers, e.g., pancreatic, lung, head-and-neck, cervical, bladder, and esophageal carcinoma.
View Article and Find Full Text PDFAdvanced glycation end-product crosslinking activates a type VI secretion system phospholipase effector protein.
Nat Commun
October 2024
Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, Santa Barbara, 93106, USA.
Article Synopsis
- Advanced glycation end-products (AGE) are harmful protein modifications linked to serious health issues like neurodegenerative diseases, heart disease, and diabetes, caused by toxic byproducts of glucose metabolism.
- Research reveals that AGE crosslinking activates a specific antibacterial enzyme in the bacteria Enterobacter cloacae, which is linked through a unique interaction between two amino acids.
- The study highlights that glycation can stabilize protein structures, especially in environments where traditional stabilizing methods (like disulfide bonds) are not effective, suggesting broader implications for protein engineering.
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