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Tracing the paths of modular evolution by quantifying rearrangement events of protein domains.
BMC Ecol Evol
January 2025
Institute for Evolution and Biodiversity, University of Münster, Münster, 48159, Germany.
Background: Protein evolution is central to molecular adaptation and largely characterized by modular rearrangements of domains, the evolutionary and structural building blocks of proteins. Genetic events underlying protein rearrangements are relatively rare compared to changes of amino-acids. Therefore, these events can be used to characterize and reconstruct major events of molecular adaptation by comparing large data sets of proteomes.
View Article and Find Full Text PDFEvaluating the Impact of N-Glycan Sequon Removal in the p27 Peptide on RSV F Protein Immunogenicity and Functionality.
Viruses
November 2024
Laboratory for Microbiology, Parasitology and Hygiene, Infla-Med Centre of Excellence, University of Antwerp (UA), Universiteitsplein 1 S.7, 2610 Antwerp, Belgium.
Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections in young children, elderly and immunocompromised patients worldwide. The RSV fusion (F) protein, which has 5-6 N-glycosylation sites depending on the strain, is a major target for vaccine development. Two to three of these sites are located in the p27 peptide, which is considered absent in virions.
View Article and Find Full Text PDFCoffee Leaf Rust Disease Detection and Implementation of an Edge Device for Pruning Infected Leaves via Deep Learning Algorithms.
Sensors (Basel)
December 2024
Institute of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8577, Japan.
Global warming and extreme climate conditions caused by unsuitable temperature and humidity lead to coffee leaf rust () diseases in coffee plantations. Coffee leaf rust is a severe problem that reduces productivity. Currently, pesticide spraying is considered the most effective solution for mitigating coffee leaf rust.
View Article and Find Full Text PDFAnalysis of Efflux Pump Contributions and Plasmid-Mediated Genetic Determinants in Ciprofloxacin-Resistant .
Pathogens
December 2024
College of Public Health, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.
This study aimed to explore the interactions among genetic determinants influencing ciprofloxacin resistance in . Treatment with PAβN, an efflux pump inhibitor, resulted in a 4-32-fold reduction in the minimum inhibitory concentration (MIC) across all 18 ciprofloxacin-resistant isolates. Notably, isolates without point mutations reverted from resistance to sensitivity.
View Article and Find Full Text PDFInterleukin-2 receptor signaling acts as a checkpoint that influences the distribution of regulatory T cell subsets.
iScience
December 2024
Department of Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Regulatory T cells (Tregs) require IL-2 for survival in the periphery, yet how IL-2 shapes Treg heterogeneity remains poorly defined. Here we show that inhibition of IL-2R signaling in post-thymic Tregs leads to a preferential early loss of circulating Tregs (cTregs). Gene expression of cTregs was more dependent on IL-2R signaling than effector Tregs (eTregs).
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