Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Elucidation of Antimicrobials and Biofilm Inhibitors Derived from a Polyacetylene Core.
Molecules
December 2024
Department of Chemistry, William & Mary, Williamsburg, VA 23185, USA.
The development of new antibiotics with unique mechanisms of action is paramount to combating the growing threat of antibiotic resistance. Recently, based on inspiration from natural products, an asymmetrical polyacetylene core structure was examined for its bioactivity and found to have differential specificity for different bacterial species based on the substituents around the conjugated alkyne. This research further probes the structural requirements for bioactivity through a systematic synthesis and investigation of new compounds with variable carbon chain length, alkynyl subunits, and alcohol substitution.
View Article and Find Full Text PDFIdentification of New Polyacetylenes from with PPAR-α Activity Study.
Molecules
December 2024
Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, Republic of Korea.
Leveille is a traditional medicine used to treat migraine headache and dysmenorrhea. In this study, three polyacetylenes, methyl (10,9,16)-16-acetoxy-9-hydroxyoctadeca-10,17-dien-12,14-diynoate (), methyl (10,9,16)-9,16-dihydroxyoctadeca-10-en-12,14-diynoate (), and methyl (10,9,16)-9,16-dihydroxyoctadeca-10,17-dien-12,14-diynoate (), were isolated from the aerial parts of . , together with seven known compounds (-).
View Article and Find Full Text PDFBiomolecule-functionalized polydiacetylene assembly for visual and on-site sensing of (E)-2-hexenal in fruits.
J Food Sci
December 2024
Zhejiang Key Laboratory for Agri-Food Processing, Key Laboratory of Agri-Products Postharvest Handling of Ministry of Agriculture and Rural Affairs, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, China.
(E)-2-Hexenal (E2H) is an important volatile organic compound (VOC) that can serve as a marker for fruit quality sensing and shelf-life evaluation. However, visual and portable sensors for E2H have not been reported mainly because of the difficulty in selective response to E2H while avoiding interference from other VOC, especially isomers. Herein, we developed a novel colorimetric sensor based on thiol-functionalized polydiacetylene assembly (PDA-SH/PDA) for the quantitative and selectivity of E2H.
View Article and Find Full Text PDFTPDYs: strained macrocyclic diynes for bioconjugation processes.
Chem Commun (Camb)
January 2025
Department of Chemistry and Centre for Green Chemistry and Catalysis, Université de Montréal, 1375 Avenue Thérèse-Lavoie-Roux, Montréal, QC, H2V 0B3, Canada.
A terphenyl diyne (TPDY) macrocycle, 3,5-TPDY, has been developed incorporating a bent 1,3-diyne that is active in SPAAC processes affording atropoisomeric triazole products, as well as cycloadditions with diazoacetates and tetrazines. A pendant amine allowed bioconjugation of TPDY to two proteins in a microbial transglutaminase-catalyzed reaction. In contrast to many cycloalkyne SPAAC reagents, the TPDY stabilization occurs interactions of π and π* orbitals of the adjacent alkynes.
View Article and Find Full Text PDFThe preparation of CuM/SiO (M = Bi, Mg, Mn) catalysts applied in ethynylation of formaldehyde for 1,4-butynediol synthesis: the positive interface effect of CuO and BiO.
Dalton Trans
January 2025
Key Laboratory of Oil and Gas Fine Chemicals, Ministry of Education and Xinjiang Uyghur Autonomous Region, School of Chemical Engineering and Technology, Xinjiang University, Urumqi, 830017, China.
The ethynylation of formaldehyde catalyzed by Cu-based catalysts is an important synthesis method for 1,4-butynediol relating to high-value-added chemicals. In this work, a series of CuM/SiO (M = Bi, Mg, Mn) catalysts were prepared by a deposition-precipitation method and applied in the ethynylation reaction. The effects of different promoters (Bi, Mg, Mn) on the catalytic activity were investigated.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!