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Associations between milk infrared-predicted plasma biomarkers of stress resilience and fertility in dairy cattle: Insights for enhancing breeding programs and herd management.
J Dairy Sci
February 2025
Department of Agronomy, Food, Natural Resources, Animals and Environment (DAFNAE), University of Padova, 35020 Legnaro (PD), Italy.
Fertility is a crucial aspect of dairy herd efficiency and sustainability. Among factors influencing fertility in dairy cattle, metabolic stress and systemic inflammation of animals are of main relevance, especially in the postpartum stage when ovarian activity begins and cows are inseminated. Our study aimed to infer the associations between milk infrared-predicted blood biomarkers of stress resilience and fertility traits, namely the interval from calving to first service (iCF), days open (DO), and the pregnancy rate at first service (PRF) in a multibreed population of 89,097 dairy cows.
View Article and Find Full Text PDFObeticholic acid's effect on HDL function in MASH varies by diabetic status.
Lipids
November 2024
Department of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, Ohio, USA.
Inflammation and oxidative stress are the key factors in the pathogenesis of both metabolic dysfunction-associated steatohepatitis (MASH) and atherosclerosis. Obeticholic acid (OCA), a farnesoid X receptor (FXR) agonist, improves hepatic inflammation and fibrosis in patients with MASH. However, it also reduces HDL cholesterol, suggesting that OCA may increase cardiovascular disease (CVD) risk in patients with MASH.
View Article and Find Full Text PDFUnraveling metabolic stress response in dairy cows: Genetic control of plasma biomarkers throughout lactation and the transition period.
J Dairy Sci
November 2024
Department of Animal Science, Food and Nutrition-DIANA, Università Cattolica del Sacro Cuore, 29122 Piacenza, Italy; Romeo and Enrica Invernizzi Research Center on Sustainable Dairy Production-CREI, Università Cattolica del Sacro Cuore, 29122 Piacenza, Italy. Electronic address:
Breeding animals able to effectively respond to stress could be a long-term, sustainable, and affordable strategy to improve resilience and welfare in livestock systems. In the present study, the concentrations of 29 plasma biomarkers were used as candidate endophenotypes for metabolic stress response in single-SNP, gene- and haplotype-based GWAS using 739 healthy lactating Italian Holstein cows and 88,271 variants. Significant genetic associations were found in all the 3 GWAS approaches for plasma γ-glutamyl transferase concentration on BTA17, for paraoxonase on BTA4, and for alkaline phosphatase and zinc on BTA2.
View Article and Find Full Text PDFSemaglutide-Induced Lupus Erythematosus With Multiorgan Involvement.
Cureus
March 2024
Internal Medicine, Hackensack Meridian Mountainside Medical Center, Montclair, USA.
Article Synopsis
- A 76-year-old woman developed a petechial rash and other symptoms after starting semaglutide, leading to her hospitalization and subsequent treatment.
- Initial tests showed liver dysfunction and mild cirrhosis, while autoimmune tests indicated possible drug-induced lupus and overlap syndrome with autoimmune hepatitis.
- Her condition improved with corticosteroids, and she was discharged with follow-up plans, highlighting the importance of monitoring for side effects related to GLP-1 receptor agonists like semaglutide.
Reduction of molecular oxygen in flavodiiron proteins - Catalytic mechanism and comparison to heme-copper oxidases.
J Inorg Biochem
June 2024
Department of Biochemistry and Biophysics, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.
The family of flavodiiron proteins (FDPs) plays an important role in the scavenging and detoxification of both molecular oxygen and nitric oxide. Using electrons from a flavin mononucleotide cofactor molecular oxygen is reduced to water and nitric oxide is reduced to nitrous oxide and water. While the mechanism for NO reduction in FDPs has been studied extensively, there is very little information available about O reduction.
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