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SMAD5 as a novel gene for familial pulmonary arterial hypertension.
Clin Sci (Lond)
January 2025
Center for Pulmonary Hypertension, Thoraxklinik Heidelberg gGmbH at Heidelberg University Hospital, Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.
Article Synopsis
- A study on 325 pulmonary arterial hypertension (PAH) patients found mutations in 23% using a specific gene panel targeting 18 known PAH genes.
- Additional sequencing identified two variants in the SMAD5 gene, which were further characterized through various functional tests, confirming their expression and effects on cell behavior.
- One variant was linked to a familial history of PAH and resulted in increased cell viability, while the other variant, associated with congenital heart disease, led to reduced cell viability due to increased apoptosis; both were deemed likely pathogenic and indicate SMAD5 as a potential new PAH gene for diagnostic testing.
Comparison of the effects of crizotinib as monotherapy and as combination therapy with butyric acid on different breast cancer cells.
Oncol Lett
January 2025
Department of Biology, Faculty of Science, Istanbul University, Istanbul 34459, Turkey.
In recent years, there have been significant developments using combined therapies in cancer treatment. The present study aimed to determine the effects of using crizotinib alone and in combination with butyric acid on different types of breast cancer cells. A total of three different breast cancer models were used: MDA-MB-231, a triple negative model; MCF-7, a Luminal A model; and SKBR-3 cell line, a human epidermal growth factor receptor 2 positive model.
View Article and Find Full Text PDFFacade eluates affect active and total soil microbiome.
Environ Pollut
January 2025
Institute for Bioanalysis, Department of Applied Sciences, Coburg University of Applied Sciences and Arts, Coburg, Germany; Bayreuth Center of Ecology and Environmental Research (BayCEER), University of Bayreuth, Bayreuth, Germany. Electronic address:
The application of biocides in building materials has become a prevalent practice to mitigate the growth of microorganisms such as algae, fungi, and bacteria on the façades. These can leach out from the material and reach the nearby soil environment. This study aimed to characterize the effect of façade eluates generated within different leaching experiments on total and metabolic active soil microbial community composition and functions.
View Article and Find Full Text PDFCytocompatibility Analysis and Comparison of Different Hyaluronic Acid Fillers for Minimally Invasive Esthetics.
In Vivo
June 2024
Clinic and Policlinic for Dermatology and Venereology, University Medical Center Rostock, Rostock, Germany;
Background/aim: To overcome the natural visual consequences of the physiological aging process, the use of biodegradable fillers made of hyaluronic acid or sodium carboxymethyl cellulose is increasingly popular in modern esthetic medicine. Clinicians can choose from a wide range of fillers with variable compositions and rheological properties, and therefore with different application areas and injection depths. The aim of this study was to analyze and compare the most commonly used fillers for facial augmentation regarding their in vitro biocompatibility and to find potential correlations to their rheological properties.
View Article and Find Full Text PDFObjectives: Aging and excessive fat intake may additively induce dysbiosis of the gut microbiota and intestinal inflammatory damage. Here, we analyzed microbiota dysbiosis and intestinal injury in high-fat diet-loaded senescence-accelerated mice (SAMP8). Additionally, we examined whether treatment with molecular hydrogen could improve the intestinal environment.
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