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Genetically modified chickens as bioreactors for protein-based drugs.
Front Genome Ed
January 2025
Frontiers Science Center for Molecular Design Breeding (MOE), State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Protein drug production encompasses various methods, among which animal bioreactors are emerging as a transgenic system. Animal bioreactors have the potential to reduce production costs and increase efficiency, thereby producing recombinant proteins that are crucial for therapeutic applications. Various species, including goats, cattle, rabbits, and poultry, have been genetically engineered to serve as bioreactors.
View Article and Find Full Text PDFA STAND-ALONE TOOL FOR MOSQUITO EGG ENUMERATION.
J Am Mosq Control Assoc
January 2025
Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, 30602.
Accurate enumeration of mosquito eggs is crucial for various entomologic studies, including investigations into mosquito fecundity, life history traits, and vector control strategies. Traditional manual counting methods are labor intensive and prone to human error, highlighting the need for automated systems. This study presents a stand-alone automated mosquito egg counting system using a Raspberry Pi computer, high-quality camera, light-emitting diode ring light source, and a Python script leveraging the Open Source Computer Vision library.
View Article and Find Full Text PDFReasons to be fearful? Rising proportions of positive faecal worm egg counts among UK horses (2007-2023).
Equine Vet J
January 2025
Equine Infectious Disease Surveillance (EIDS), Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Background: Anthelmintic resistance (AR) threatens effective equine parasite control. Quarterly data summaries from faecal worm egg count testing (FWECT) performed by UK laboratories have appeared in Equine Quarterly Disease Surveillance Reports (EQDSR) since 2007, but have not previously been assessed.
Objectives: To assess strongyle FWECT methods and thresholds used by UK laboratories.
WDR74-Mediated Ribosome Biogenesis and Proteome Dynamics During Mouse Preimplantation Development.
Genes Cells
January 2025
Advanced Biological Information Research Division, INAMORI Frontier Research Center, Kyushu University, Fukuoka, Japan.
Preimplantation embryonic development is orchestrated by dynamic changes in the proteome and transcriptome, regulated by mechanisms such as maternal-to-zygotic transition. Here, we employed label-free quantitative proteomics to comprehensively analyze proteome dynamics from germinal vesicle oocytes to blastocysts in mouse embryos. We identified 3490 proteins, including 715 consistently detected across all stages, revealing stage-specific changes in proteins associated with translation, protein modification, and mitochondrial metabolism.
View Article and Find Full Text PDFHistorically Polluted Area Increases Human Exposure Risks to Polychlorinated Naphthalenes through Waterfowl Egg Consumption.
Environ Health (Wash)
January 2025
Institute of Quality Standards and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
Polychlorinated naphthalenes (PCNs), which are ubiquitous in the environment, are listed as persistent organic pollutants under the Stockholm Convention. Poultry can be exposed to PCNs via feed and breeding environments, leading to PCNs accumulation in eggs. However, information on PCNs in eggs from waterfowl raised in contaminated regions is scarce.
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