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Proximity Effects and Aggregation of Hamilton-Receptor Barbiturate Host-Guest Complexes Probed by Cross-Metathesis and ESI MS Analysis.
Chemistry
November 2024
Faculty of Natural Science II, Institute of Chemistry, Macromolecular Chemistry, Martin Luther University Halle-Wittenberg, von-Danckelmann-Platz 4, Halle/Saale, D-06120, Germany.
The molecular environment around supramolecular bonding systems significantly affects their stability and the assembly of host-guest complexes, most prominent for hydrogen bonds (H-bonds). Hamilton receptor-barbiturate host-guest complexes are well-known in solution, typically forming a 1 : 1 molar ratio complex. However, within a polymer matrix, these complexes can form higher-order assemblies, deviating from the standard 1 : 1 complex, which are challenging to characterize and often require lab-intensive methods.
View Article and Find Full Text PDFIntegrated Population Pharmacokinetics of Daprodustat in Patients with Chronic Kidney Disease with Anemia.
Clin Pharmacokinet
September 2024
Leiden Experts on Advanced Pharmacokinetics and Pharmacodynamics (LAP&P), Leiden, The Netherlands.
Article Synopsis
- - Daprodustat, a new treatment for anemia in chronic kidney disease (CKD) patients, was analyzed to understand how various factors affect its pharmacokinetics in adults, focusing on its absorption, distribution, metabolism, and excretion in dialysis and non-dialysis patients.
- - The study involved data from multiple clinical trials with 707 participants, examining how body weight and the use of certain medications (like clopidogrel) influenced daprodustat's clearance and absorption.
- - Results indicated that daprodustat followed a three-compartment distribution model with specific influences from body weight and dialysis status, while other factors did not significantly impact the drug's effectiveness.
Pharmacokinetic analysis of a phenobarbital overdose treated with urinary alkalinization alone.
Toxicol Rep
June 2024
Division of Medical Toxicology, Department of Emergency Medicine, UC San Diego Health, CA, USA.
Article Synopsis
- - Phenobarbital is a long-acting barbiturate used for treating alcohol withdrawal and epilepsy but can cause severe central nervous system depression in case of overdose.
- - A case study of a 14-year-old girl showed that urinary alkalinization with sodium bicarbonate was used successfully for treating phenobarbital overdose, enhancing drug elimination.
- - Despite the treatment increasing urinary excretion rates, there was no significant impact on the elimination half-life of the drug, indicating the need for further studies on the efficacy of urinary alkalinization in such cases.
A colorimetric and NIR fluorescent probe for ultrafast detecting bisulfite and organic amines and its applications in food, imaging, and monitoring fish freshness.
Food Chem
April 2024
College of Chemistry and Materials Engineering, Jinzhou 121013, China; College of Food Science and Technology, Jinzhou 121013, China; Institute of Ocean, Bohai University, Jinzhou 121013, China; Food Safety Key Lab of Liaoning Province, Jinzhou 121013, China; National & Local Joint Engineering Research Center of Storage, Processing and Safety Control Technology for Fresh Agricultural and Aquatic Products, Jinzhou 121013, China.
Herein, for the first time, we have successfully constructed a novel near-infrared (NIR) emission fluorescent probe Dpyt for ultrafast detecting (within 5 s) bisulfate and organic amines based on a 1,2-dihydrocyclopenta[b]chromene-barbiturate conjugation system. Upon addition of bisulfate or organic amines, Dpyt displayed a distinct color change from blue to colorless or from purple to blue, respectively, suggesting that the Dpyt can be used to detect two analytes by the naked eye. Based on quantum chemistry calculations, the fluorescence quenching of Dpyt after the addition of HSO is caused by the photoinduced electron transfer (PET) process of the adduct Dpyt-HSO.
View Article and Find Full Text PDFDeep Sedation in Traumatic Brain Injury Patients.
Korean J Neurotrauma
June 2023
Department of Neurosurgery, Soonchunhyang University Cheonan Hospital, College of Medicine, Soonchunhyang University, Cheonan, Korea.
Article Synopsis
- Traumatic brain injury (TBI) significantly contributes to adult mortality and disability, with severe cases posing challenges in managing intracranial hypertension during treatment.
- *Deep sedation can help manage intracranial pressure (ICP) while providing patient comfort, but it requires careful balance to avoid both insufficient and excessive sedation.
- *This review highlights the importance of monitoring sedation levels and discusses effective techniques and sedatives used in TBI management, specifically focusing on barbiturates and propofol.
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