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Investigation of the threonine metabolism of Echinococcus multilocularis: The threonine dehydrogenase as a potential drug target in alveolar echinococcosis.
Int J Parasitol Drugs Drug Resist
January 2025
Institute of Parasitology, Vetsuisse Faculty, University of Bern, Bern, Switzerland; Multidisciplinary Center for Infectious Diseases, University of Bern, Bern, Switzerland. Electronic address:
Alveolar echinococcosis (AE) is a severe zoonotic disease caused by the metacestode stage of the fox tapeworm Echinococcus multilocularis. We recently showed that E. multilocularis metacestode vesicles scavenge large amounts of L-threonine from the culture medium.
View Article and Find Full Text PDFTransferBAN-Syn: a transfer learning-based algorithm for predicting synergistic drug combinations against echinococcosis.
Front Genet
January 2025
Key Laboratory of Intelligent Computing and Signal Processing, School of Artificial Intelligence, Anhui University, Hefei, China.
Echinococcosis is a zoonotic parasitic disease caused by the larvae of echinococcus tapeworms infesting the human body. Drug combination therapy is highly valued for the treatment of echinococcosis because of its potential to overcome resistance and enhance the response to existing drugs. Traditional methods of identifying drug combinations via biological experimentation is costly and time-consuming.
View Article and Find Full Text PDFDesigning multi-epitope vaccines against Echinococcus granulosus: an in-silico study using immuno-informatics.
BMC Mol Cell Biol
December 2024
Department of Biochemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
Cystic echinococcosis (CE) is a worldwide zoonotic public health issue. The reasons for this include a lack of specific therapy options, increasing antiparasitic drug resistance, a lack of control strategies, and the absence of an approved vaccine. The aim of the current study is to develop a multiepitope vaccine against CE by in-silico identification and using different Antigen B subunits.
View Article and Find Full Text PDFEchinococcus granulosus sensu lato control measures: a specific focus on vaccines for both definitive and intermediate hosts.
Parasit Vectors
December 2024
State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Xinjiang Medical University, Urumqi, China.
Echinococcosis, a neglected zoonotic disease caused by Echinococcus tapeworms, presents significant public health challenges worldwide. Cystic and alveolar echinococcosis has substantial health and economic impacts, necessitating effective prevention and control strategies. The present review provides a framework to expand our knowledge regarding key components of echinococcosis prevention and control, including phases, options, targets and available tools as well as current gaps and challenges in the field.
View Article and Find Full Text PDFSpinal hydatid disease: a case report - an uncommon differential diagnosis in LMICs.
Ann Med Surg (Lond)
December 2024
Department of Neurosurgery, Neurosurgery Clinic, Birgunj, Nepal.
Article Synopsis
- Spinal hydatid disease is a rare condition, occurring in only 0.2-1% of cases, mainly in regions where it is common, and should be considered in spinal cord compression diagnoses.
- The case involved a 52-year-old man with symptoms like lower extremity pain, trouble urinating, and back issues, who was treated with antiparasitic therapy and underwent two surgeries with no bacteria found post-treatment.
- Early detection and proper treatment are essential due to the rarity of the disease, emphasizing its importance in differential diagnosis for spinal issues.
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