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Linking oxytocin to nicotine dependence: An experimental study of the brain, behavior, and gut microbiota in rats.
Neurosci Lett
March 2025
China National Tobacco Quality Supervision &Test Center, Zhengzhou 450000, China; Beijing Life Science Academy, Beijing 100000, China; Key Laboratory of Tobacco Biological Effects, Zhengzhou 450000, China.
Oxytocin (OXT) is a hypothalamic neuropeptide, and numerous studies have indicated that exposure to addictive substances, such as opioids, cocaine, etc., can result in decreased function of the OXT system. The study also found that OXT can reduce addictive behavior for certain drugs, including methamphetamine, alcohol, and cocaine, suggesting a close relationship between the OXT system and drug abuse.
View Article and Find Full Text PDFOxytocin receptors within the caudal lateral septum regulate social approach-avoidance, long-term social discrimination, and anxiety-like behaviors in adult male and female rats.
Neuropharmacology
March 2025
Biological Sciences Department, Brock University, Canada; Psychology Department, Brock University, Canada. Electronic address:
OTR signaling promotes social approach or facilitates social avoidance, depending on the brain region involved. The lateral septum plays a critical role in regulating social interactions and memory. We investigated the role of OTR signaling in the caudodorsal lateral septum (LSc.
View Article and Find Full Text PDFA Low-Dose Oxytocin Protocol Decreases Quantitative Blood Loss in Elective Cesarean Sections: A Single-Center, Retrospective Cohort Study.
Mil Med
March 2025
Brooke Army Medical Center, Joint Base San Antonio, Fort Sam Houston, TX 78234, USA.
Introduction: The prophylactic use of oxytocin after cesarean delivery has been shown to reduce maternal blood loss by 40 to 50%, yet there remains significant clinical deviation in how the medication is dosed. In January, 2021, the Defense Health Agency issued Procedural Instruction 6025.35 entitled Guidance for Implementation of the Postpartum Hemorrhage Bundle.
View Article and Find Full Text PDFA Snapshot Survey of Uterotonic Administration Practice During Cesarean Section: Is There a Difference Between the Attitudes of Obstetricians and Anesthesiologists?
Medicina (Kaunas)
February 2025
Department of Anesthesiology and Reanimation, Gazi University School of Medicine, 06500 Ankara, Turkey.
: We aimed to evaluate the current uterotonic administration practices among anesthesiologists and obstetricians and gynecologists (OBGYNs) during cesarean section (CS), focusing on variations in approaches for low- and high-risk postpartum hemorrhage (PPH) cases. The objective was to identify key differences and provide evidence that could contribute to the development of standardized national protocols for uterotonic usage. : A snapshot online survey was employed between October 2021 and January 2022 and distributed to anesthesiologists and OBGYNs from university-affiliated, government, and private hospitals across Turkey, consisting of 23 questions addressing demographic data, institutional PPH rates, first-line uterotonic choices, administration methods, and dose adjustments for low- and high-risk PPH cases.
View Article and Find Full Text PDFImplementation of an oxytocin bolus protocol for cesarean delivery at a Texas level IV maternal center: a single-center retrospective study.
Proc (Bayl Univ Med Cent)
January 2025
Department of Anesthesiology, Baylor Scott & White Medical Center - Temple, Temple, Texas, USA.
Objective: We hypothesized that patients who underwent cesarean delivery and received oxytocin boluses followed by an infusion would have a lower incidence of secondary uterotonic administration compared to patients who had an oxytocin infusion without boluses.
Methods: Patients who had cesarean deliveries at our hospital from September 1, 2021 through December 31, 2021 and from September 1, 2022 through December 31, 2022, corresponding to the oxytocin bolus and oxytocin infusion cohorts, respectively, were included. Patient demographic, physical, and clinical characteristic data were collected by a study investigator.
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