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The Modulatory Effect of Selol (Se IV) on Pro-Inflammatory Pathways in RAW 264.7 Macrophages.
Int J Mol Sci
January 2025
Chair and Department of Biochemistry, Medical University of Warsaw, Banacha 1, 02-097 Warszawa, Poland.
Selol is a semi-synthetic mixture of selenized triglycerides. The results of biological studies revealed that Selol exhibits several anticancer effects. However, studies on its potential anti-inflammatory activity are scarce, and underlying signaling pathways are unknown.
View Article and Find Full Text PDFComparing the Structural and Physicochemical Properties of Highland Barley -Glucan from Different Sources: A Focus on Color.
Foods
January 2025
Shandong Key Laboratory of Healthy Food Resources Exploration and Creation, School of Food Sciences and Engineering, Qilu University of Technology, Shandong Academy of Sciences, Daxue Road, Changqing District, Jinan 250353, China.
Herein, -glucan (BG) was extracted from different colored varieties of highland barley (HB, ), defined as BBG, WBG, and LBG depending on the colors of black, white, and blue and their molecular structure and physicochemical properties were investigated through a series of technical methods. The high-performance anion-exchange chromatography (HPAEC) results indicated the extracted BBG, LBG, and WBG mainly comprised glucose regardless of color. The molecular weight (M) of BBG, LBG, and WBG were 55.
View Article and Find Full Text PDFSuccinate receptor 1 signaling mutually depends on subcellular localization and cellular metabolism.
FEBS J
January 2025
Rudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Germany.
Succinate is a pivotal tricarboxylic acid cycle metabolite but also specifically activates the G- and G-coupled succinate receptor 1 (SUCNR1). Contradictory roles of succinate and succinate-SUCNR1 signaling include reports about its anti- or pro-inflammatory effects. The link between cellular metabolism and localization-dependent SUCNR1 signaling qualifies as a potential cause for the reported conflicts.
View Article and Find Full Text PDFSimultaneous determination of naphthalimide-labelled monosaccharides in . Hua. polysaccharides utilizing the HPLC-UV technique.
Anal Methods
January 2025
Key Laboratory of Xin'an Medicine of the Ministry of Education, College of Chinese Medicine, School of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230038, P. R. China.
4-Amidogen-1,8-naphthalimide (ANA), a novel pre-column derivatization reagent, has been successfully synthesized and utilized for the highly sensitive analysis of monosaccharides. ANA reacts with the reducing carbonyl groups of saccharides, facilitating monosaccharide detection. The resulting monosaccharide derivatives were meticulously investigated using High-Performance Liquid Chromatography (HPLC) coupled with ultraviolet (UV) spectroscopy.
View Article and Find Full Text PDFStructural analysis and anti-hepatic fibrosis effects of a homogeneous polysaccharide from Radix Puerariae lobatae (Willd.) Ohwi roots.
Int J Biol Macromol
January 2025
Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, Wannan Medical College, Wuhu 241002, China; Anhui Provincial Engineering Laboratory for Screening and Re-evaluation of Active Compounds of Herbal Medicines in Southern Anhui, Wannan Medical College, Wuhu 241002, China; Anhui Provincial Engineering Research Center for Polysaccharide Drugs, Wannan Medical College, Wuhu 241002, China; Anhui Innovative Center for Drug Basic Research of Metabolic Diseases, Wannan Medical College, Wuhu 241002, China; Wuhu Modern Technology Research and Development Center of Chinese herbal Medicines and Functional Foods, Anhui College of Traditional Chinese Medicine, Wuhu 241002, China. Electronic address:
Radix Pueraria lobata (Willd.) Ohwi, renowned for its medicinal properties, has garnered significant research interest, particularly in its polysaccharide components. In this study, a novel water-soluble polysaccharide (50PLP) was isolated and characterized from P.
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