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Anti-inflammatory effects of moxifloxacin and levofloxacin on cadmium-activated human astrocytes: Inhibition of proinflammatory cytokine release, TLR4/STAT3, and ERK/NF-κB signaling pathway.
PLoS One
January 2025
Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samut Prakan, Thailand.
Cadmium is a non-essential element and neurotoxin that causes neuroinflammation, which leads to neurodegenerative diseases and brain cancer. To date, there are no specific or effective therapeutic agents to control inflammation and alleviate cadmium-induced progressive destruction of brain cells. Fluoroquinolones (FQs), widely used antimicrobials with effective blood-brain barrier penetration, show promise in being repurposed as anti-inflammatory drugs.
View Article and Find Full Text PDFAnalysis of growth physiological changes and metabolome of highland barley seedlings under cadmium (II) stress.
Environ Pollut
January 2025
Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Sichuan Engineering & Technology Research Center of Coarse Cereal Industrialization, School of Food and Biological Engineering, Chengdu University, Chengdu, Sichuan, China. Electronic address:
This study aims to investigate the physiological changes in growth and metabolic response mechanisms of highland barley under different concentrations of cadmium. To achieve this, cadmium stress was applied to green barley at levels of 20, 40, and 80 mg/L. The results revealed that, under Cd(II) stress, the chlorophyll content and photosynthesis in leaves of highland barley seedlings were inhibited to some extent.
View Article and Find Full Text PDFRoles of N-methyladenosine in LncRNA changes and oxidative damage in cadmium-induced pancreatic β-cells.
Toxicology
January 2025
School of Public Health, Dali University, Dali, Yunnan, China; Institute of Preventive Medicine, Dali University, Dali, Yunnan, China. Electronic address:
N-methyladenosine (mA) modification and LncRNAs play crucial regulatory roles in various pathophysiological processes, yet roles of mA modification and the relationship between mA modification and LncRNAs in cadmium-induced oxidative damage of pancreatic β-cells have not been fully elucidated. In this study, mA agonist entacapone and inhibitor 3-deazadenosine were used to identify the effects of mA on cadmium-induced oxidative damage as well as LncRNA changes. Our results indicate that elevated levels of mA modification by entacapone can rescue the cell viability and attenuate the cell apoptosis, while the inhibition levels of mA modification can exacerbate the cell death.
View Article and Find Full Text PDFThe combination of metagenomics and metabolomics reveals the effect of nitrogen fertilizer application driving the remobilization of immobilization remediation cadmium and rhizosphere microbial succession in rice.
J Hazard Mater
January 2025
College of Chemical and Environmental Engineering, Hanjiang Normal University, Shiyan 442000, China. Electronic address:
Article Synopsis
- The study examined how adding nitrogen fertilizers affects the remobilization of cadmium in rice fields, highlighting increased cadmium levels in rice due to ammonia nitrogen (NH-N) compared to nitrogen (NO-N).
- Organic acids secreted by rice roots, particularly under NH-N treatment, were found to play a significant role in increasing soluble cadmium content and impacting microbial community functions.
- The research suggests a complex interaction between nutrient application, cadmium levels, and microbial dynamics that could elevate cadmium exposure through rice consumption.
γ-Aminobutyric Acid Alleviates Programmed Cell Death in Two Species Under Cadmium Stress.
Int J Mol Sci
December 2024
College of Resources, Sichuan Agricultural University, Chengdu 611130, China.
Previous studies have demonstrated that γ-Aminobutyric acid (GABA) effectively alleviates heavy metal stresses by maintaining the redox balance and reducing the accumulation of reactive oxygen species (ROS). However, little is known about the role of GABA on programmed cell death (PCD) under Cd treatments in plants. The present study investigated the effects of GABA on Cd-induced PCD in two species, oilseed rape (, ), and black mustard (, ).
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